CALD1

Gene Symbol CALD1
Entrez Gene 800
Alt Symbol CDM, H-CAD, HCAD, L-CAD, LCAD, NAG22
Species Human
Gene Type protein-coding
Description caldesmon 1
Other Description caldesmon
Swissprots Q13979 Q14742 Q9UD91 Q05682 Q14741 Q13978 A8K0X1
Accessions CAJ29926 EAW83826 EAW83827 EAW83828 EAW83830 EAW83831 EAW83832 EAW83833 EAW83834 EAW83835 Q05682 AB062484 BAB93509 AF247820 AAF69498 AF315788 AI926727 AJ223812 AK021691 AK022222 AK022456 AK289686 BAF82375 AK298524 BAG60727 AK300282 BAH13250 AK304729 BAG65492 AL601004 AU134367 BC005006 AAH05006 BC014035 AAH14035 BC015839 BC040354 AAH40354 BC061926 AAH61926 BF675655 BF965359 BQ010124 BU683034 BX538339 CAD98104 BX648808 BX649088 CAI46261 CA433571 CA447404 CD359921 CK821334 CN314587 CV573441 D90452 BAA14418 D90453 BAA14419 DA323544 DA546174 DB090561 M64110 AAA35636 M83216 AAA58419 XM_006716136 XP_006716199 XM_006716139 XP_006716202 XM_011516585 XP_011514887 XR_927534 XR_927535 XR_927536 XR_927537 XR_927538 XR_927539 XR_927540 XR_927541 XR_927542 NM_004342 NP_004333 NM_033138 NP_149129 NM_033139 NP_149130 NM_033140 NP_149131 NM_033157 NP_149347
Function Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril {ECO:0000250}. Note=On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle). {ECO:0000250}.
Tissue Specificity High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular- weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
Top Pathways Vascular smooth muscle contraction

Caldesmon-1 (D5C8D) XP ® Rabbit mAb - 12503 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5C8D
Western blot analysis of extracts from various cell lines using Caldesmon-1 (D5C8D) XP ® Rabbit mAb (upper) or α-Actinin (D6F6) XP ® Rabbit mAb #6487 (lower).

Caldesmon-1 Antibody - 2980 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types using Caldesmon-1 Antibody.

Caldesmon (A-2) - sc-271222 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Caldesmon (A-2): sc-271222. Immunoperoxidase staining of formalin fixed, paraffin-embedded human smooth muscle tissue showing cytoplasmic staining of smooth muscle cells.

Caldesmon (C-19) - sc-7574 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Caldesmon (C-19): sc-7574. Western blot analysis of L Caldesmon and H-Caldesmon expression in BC<sub>3</sub>H1 (A), A-10 (B), NIH/3T3 (C) and HISM (D) whole cell lysates.

Caldesmon (C21) - sc-58700 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Caldesmon (C21): sc-58700. Western blot analysis of Caldesmon expression in WI 38 (A), A-10 (B) and HISM (C) whole cell lysates. No detergent used in blocking/antibody dilution or washes.

Caldesmon (H-300) - sc-15374 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Caldesmon (H-300): sc-15374. Immunofluorescence staining of normal mouse intestine frozen section showing cytoskeletal staining.

Caldesmon (N-19) - sc-7575 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Caldesmon (N-19): sc-7575. Western blot analysis of H-Caldesmon expression in HeLa whole cell lysate.

Caldesmon (8) - sc-135965 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Caldesmon (8): sc-135965. Western blot analysis of L-Caldesmon expression in Hs68 tissue extract.

L-Caldesmon (F-1) - sc-48427 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
L-Caldesmon (F-1): sc-48427. Western blot analysis of L-Caldesmon expression in HeLa (A) and JAR (B) whole cell lysates.

L-Caldesmon (F-10) - sc-25339 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
L-Caldesmon (F-10): sc-25339. Immunoperoxidase staining of formalin fixed, paraffin-embedded human normal colon tissue showing cytoplasmic localization.

H-Caldesmon (h-CALD) - sc-58703 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
H-Caldesmon (h-CALD): sc-58703. Western blot analysis of H-Caldesmon expression in HISM (A) and FCH (B) whole cell lysates.

p-Caldesmon (Ser 789) - sc-12931 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-Caldesmon (Ser 789): sc-12931. Immunofluorescence staining of methanol-fixed BC<sub>3</sub>H1 cells showing cytoskeletal localization.

p-Caldesmon (Tyr 27)-R - sc-12930-R from Santa Cruz Biotechnology

Prices $61.00
Sizes 100 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
p-Caldesmon (Tyr 27): sc-12930. Western blot analysis of phosphorylated L-Caldesmon in non-transfected 293T: sc-117752 (A), truncated mouse Caldesmon transfected 293T: sc-118955 (B) and NIH/3T3 (C) whole cell lysates.

Anti-Caldesmon (phospho S759) antibody - ab111579 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Caldesmon (Phospho-Ser759) antibody (ab111579). Without blocking peptide on left and with blocking peptide on the right.

Anti-Caldesmon (phospho S759) antibody [EPR2212] - ab76106 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2212
All lanes : Anti-Caldesmon (phospho S759) antibody [EPR2212] (ab76106) at 1/3000 dilutionLane 1 : HeLa lysate, untreated Lane 2 : HeLa lysate treated with Calyculin ALysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti rabbit at 1/2000 dilution

Anti-Caldesmon (phospho S789) antibody - ab182653 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caldesmon (phospho S789) antibody (ab182653) at 1/500 dilutionLane 1 : Rat heart tissue extractLane 2 : Rat heart tissue extract with antigen-specific peptide

Anti-Caldesmon (phospho S789) antibody - ab195949 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caldesmon (phospho S789) antibody (ab195949) at 1/500 dilutionLane 1 : EGF-treated HeLa whole cell lysate with antigen-specific peptideLane 2 : EGF-treated HeLa whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-Caldesmon (phospho T730) antibody [EPR2210] - ab75758 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2210
All lanes : Anti-Caldesmon (phospho T730) antibody [EPR2210] (ab75758) at 1/10000 dilutionLane 1 : HeLa cell lysate, untreatedLane 2 : HeLa cell lysate, treated with Calyculin ALysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP at 1/2000 dilution

Anti-Caldesmon (phospho T753) antibody [EPR2211Y] - ab108356 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2211Y
All lanes : Anti-Caldesmon (phospho T753) antibody [EPR2211Y] (ab108356) at 1/1000 dilutionLane 1 : Hela cell lysate, untreated Lane 2 : Hela cell lysate, treated with Calyculin ALysates/proteins at 10 µg per lane.

Anti-Caldesmon antibody - ab58502 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caldesmon antibody (ab58502) at 1/500 dilutionLane 1 : HeLa cell extract treated with EGF (200ng/ml, 30mins)Lane 2 : HeLa cell extract treated with EGF (200ng/ml, 30mins) with immunising peptide

Anti-Caldesmon antibody - ab133224 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caldesmon antibody (ab133224) at 1/500 dilutionLane 1 : HeLa cell extracts, treated with EGF (200 ng/ml for 30 minutes)Lane 2 : HeLa cell extracts, treated with EGF (200 ng/ml for 30 minutes) with synthesized peptide

Anti-Caldesmon antibody [C21] - ab11016 from Abcam

Host Mouse
Clonality Monoclonal
Clone C21
ab11016 staining Caldesmon in Rat heart tissue sections 10 weeks after myocardial infarction by Immunohistochemistry (IHC-Fr - frozen sections). Tissue was fixed with 2% paraformaldehyde. Co-localization of: Red - caldesmon, Green - alpha smooth actin. Scale bar 50 µm.

Anti-Caldesmon antibody [E89] - ab32330 from Abcam

Prices $394.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone E89
Anti-Caldesmon antibody [E89] (ab32330) at 1/20000 dilution + NIH3T3 cell lysate

Anti-Caldesmon antibody [EP789Y] - ab45691 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP789Y
Anti-Caldesmon antibody [EP789Y] (ab45691) at 1/10000 dilution + HeLa cell lysate (10ug/lane)SecondaryGoat anti-rabbit HRP labeled at 1/2000 dilution

Anti-Caldesmon antibody [h-CALD] - ab1826 from Abcam

Host Mouse
Clonality Monoclonal
Clone h-CALD
All lanes : Anti-Caldesmon antibody [h-CALD] (ab1826) at 1/200 dilutionLane 1 : Human skeletal muscle (gastrocnemius) tissue lysate - normal patientLane 2 : Human skeletal muscle (gastrocnemius) tissue lysate - diseased patientLysates/proteins at 20 µg per lane.SecondaryAlexa Fluor® 488-conjugated Goat anti-mouse IgG polyclonal at 1/5000 dilutionPerformed under reducing conditions.
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