| Gene Symbol |
MYL12A
|
| Entrez Gene |
10627
|
| Alt Symbol |
HEL-S-24, MLC-2B, MLCB, MRCL3, MRLC3, MYL2B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
myosin, light chain 12A, regulatory, non-sarcomeric
|
| Other Description |
epididymis secretory protein Li 24|myosin RLC|myosin regulatory light chain 12A|myosin regulatory light chain 2, nonsarcomeric|myosin regulatory light chain 3|myosin regulatory light chain MRLC3|myosin, light polypeptide, regulatory, non-sarcomeric (20kD)
|
| Swissprots |
D3DUH6 Q13182 Q7Z5Z4 Q53X45 P19105 O14950
|
| Accessions |
EAX01678 EAX01679 EAX01680 EAX01681 P19105 AK222569 BAD96289 AK291145 BAF83834 AW958488 BC016372 AAH16372 BC031972 AAH31972 BC032748 AAH32748 BM561281 BU615599 CA309747 CD702288 D82059 BAB88919 DQ185044 ABD14424 DQ892814 ABM83740 DQ896060 ABM87059 EU794621 ACJ13675 X54304 CAA38201 XM_005258078 XP_005258135 NM_001303047 NP_001289976 NM_001303048 NP_001289977 NM_001303049 NP_001289978 NM_006471 NP_006462
|
| Function |
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed in various hematopoietic cells. {ECO:0000269|PubMed:11436981, ECO:0000269|PubMed:18480596}.
|
| Top Pathways |
Tight junction, Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton
|
![Western Blot: MRCL3 Overexpression Lysate (Adult Normal) [NBL1-13218] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MRCL3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6009_MRCL3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13218-img0002.jpg)