| Gene Symbol |
GGCT
|
| Entrez Gene |
79017
|
| Alt Symbol |
C7orf24, CRF21, GCTG, GGC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
gamma-glutamylcyclotransferase
|
| Other Description |
cytochrome c-releasing factor 21|gamma -glutamyl cyclotransferase
|
| Swissprots |
Q9BS37 B8ZZR8 O75223 B8ZZN4 B2RDN0
|
| Accessions |
EAL24452 EAW93950 EAW93951 EAW93952 EAW93953 O75223 AK021779 BAG51049 AK315608 BAG37977 BC000625 AAH00625 BC005356 AAH05356 BC013937 AAH13937 BC019243 AAH19243 BE407390 BE885397 BG527593 HQ448710 ADQ33188 NM_001199815 NP_001186744 NM_001199816 NP_001186745 NM_001199817 NP_001186746 NM_024051 NP_076956 NR_037669
|
| Function |
Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. {ECO:0000269|PubMed:16765912, ECO:0000269|PubMed:18515354}.
|
| Top Pathways |
Glutathione metabolism
|
![Western Blot: GGCT Overexpression Lysate (Adult Normal) [NBP2-06360] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GGCT.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7766_GGCT%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06360-img0001.jpg)