Gene Symbol | GGCT |
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Entrez Gene | 79017 |
Alt Symbol | C7orf24, CRF21, GCTG, GGC |
Species | Human |
Gene Type | protein-coding |
Description | gamma-glutamylcyclotransferase |
Other Description | cytochrome c-releasing factor 21|gamma -glutamyl cyclotransferase |
Swissprots | Q9BS37 B8ZZR8 O75223 B8ZZN4 B2RDN0 |
Accessions | EAL24452 EAW93950 EAW93951 EAW93952 EAW93953 O75223 AK021779 BAG51049 AK315608 BAG37977 BC000625 AAH00625 BC005356 AAH05356 BC013937 AAH13937 BC019243 AAH19243 BE407390 BE885397 BG527593 HQ448710 ADQ33188 NM_001199815 NP_001186744 NM_001199816 NP_001186745 NM_001199817 NP_001186746 NM_024051 NP_076956 NR_037669 |
Function | Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. {ECO:0000269|PubMed:16765912, ECO:0000269|PubMed:18515354}. |
Top Pathways | Glutathione metabolism |
CRF21 CRISPR/Cas9 KO Plasmid (h) - sc-413110 from Santa Cruz Biotechnology
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CRF21 HDR Plasmid (h) - sc-413110-HDR from Santa Cruz Biotechnology
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CRF21 Double Nickase Plasmid (h) - sc-413110-NIC from Santa Cruz Biotechnology
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CRF21 Double Nickase Plasmid (h2) - sc-413110-NIC-2 from Santa Cruz Biotechnology
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CRF21 CRISPR Activation Plasmid (h) - sc-413110-ACT from Santa Cruz Biotechnology
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CRF21 CRISPR Activation Plasmid (h2) - sc-413110-ACT-2 from Santa Cruz Biotechnology
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CRF21 Lentiviral Activation Particles (h) - sc-413110-LAC from Santa Cruz Biotechnology
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CRF21 Lentiviral Activation Particles (h2) - sc-413110-LAC-2 from Santa Cruz Biotechnology
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CRF21 siRNA (h) - sc-89714 from Santa Cruz Biotechnology
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CRF21 shRNA Plasmid (h) - sc-89714-SH from Santa Cruz Biotechnology
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CRF21 shRNA (h) Lentiviral Particles - sc-89714-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU086711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9255 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9255 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04993 from Sigma-Aldrich
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GGCT siRNA (Human) - CRJ2256 from Cohesion Biosciences
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GGCT - MBS8203873 from MyBioSource
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shRNA set against Human GC (NM_024051.3) - SHH299886 from Creative biogene
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GGCT shRNA Plasmid (Human) - CHJ2256 from Cohesion Biosciences
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GGCT miRNA 3'UTR clone - MiUTR3H-00857 from Creative biogene
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