| Gene Symbol |
RNF146
|
| Entrez Gene |
81847
|
| Alt Symbol |
dJ351K20.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 146
|
| Other Description |
2610509H23Rik|E3 ubiquitin-protein ligase RNF146|dactylidin|iduna
|
| Swissprots |
Q9NTX6 Q7L8H4 Q96T06 Q9NTX7 Q6FIB2 E1P572 Q96K03
|
| Accessions |
EAW48109 EAW48110 EAW48111 EAW48112 EAW48113 Q9NTX7 AI929027 AJ315122 CAC85986 AJ420549 AK027436 BAB55108 AK027558 BAB55196 AK027776 BAB55359 AL136829 CAB66763 AM392718 CAL37596 AM393788 CAL38663 BC008235 AAH08235 BG708628 BI669435 BI771613 CN388414 CR533514 CAG38545 DA043259 DA145911 DA639989 DA707096 DA826982 DB267873 XM_006715571 XP_006715634 XM_011536161 XP_011534463 XM_011536162 XP_011534464 XM_011536163 XP_011534465 XM_011536164 XP_011534466 NM_001242847 NM_001242848 NM_001242844 NP_001229773 NM_001242845 NP_001229774 NM_001242846 NP_001229775 NM_001242849 NP_001229778 NM_001242850 NP_001229779 NM_001242851 NP_001229780 NM_001242852 NP_001229781 NM_030963 NP_112225 NR_045102 NR_045103
|
| Function |
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective prote
|
| Subcellular Location |
Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus after DNA damage, such as laser- induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding.
|
| Tissue Specificity |
Ubiquitously expressed. Up-regulated in brains from patients with Alzheimer disease.
|
![Western Blot: RNF146 Overexpression Lysate (Adult Normal) [NBL1-15429] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RNF146.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4681_RNF146%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15429-img0002.jpg)