RNF146

Gene Symbol RNF146
Entrez Gene 81847
Alt Symbol dJ351K20.1
Species Human
Gene Type protein-coding
Description ring finger protein 146
Other Description 2610509H23Rik|E3 ubiquitin-protein ligase RNF146|dactylidin|iduna
Swissprots Q9NTX6 Q7L8H4 Q96T06 Q9NTX7 Q6FIB2 E1P572 Q96K03
Accessions EAW48109 EAW48110 EAW48111 EAW48112 EAW48113 Q9NTX7 AI929027 AJ315122 CAC85986 AJ420549 AK027436 BAB55108 AK027558 BAB55196 AK027776 BAB55359 AL136829 CAB66763 AM392718 CAL37596 AM393788 CAL38663 BC008235 AAH08235 BG708628 BI669435 BI771613 CN388414 CR533514 CAG38545 DA043259 DA145911 DA639989 DA707096 DA826982 DB267873 XM_006715571 XP_006715634 XM_011536161 XP_011534463 XM_011536162 XP_011534464 XM_011536163 XP_011534465 XM_011536164 XP_011534466 NM_001242847 NM_001242848 NM_001242844 NP_001229773 NM_001242845 NP_001229774 NM_001242846 NP_001229775 NM_001242849 NP_001229778 NM_001242850 NP_001229779 NM_001242851 NP_001229780 NM_001242852 NP_001229781 NM_030963 NP_112225 NR_045102 NR_045103
Function E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective prote
Subcellular Location Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus after DNA damage, such as laser- induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding.
Tissue Specificity Ubiquitously expressed. Up-regulated in brains from patients with Alzheimer disease.

RNF146 CRISPR/Cas9 KO Plasmid (h) - sc-417152 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF146 HDR Plasmid (h) - sc-417152-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF146 Double Nickase Plasmid (h) - sc-417152-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF146 Double Nickase Plasmid (h2) - sc-417152-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF146 CRISPR Activation Plasmid (h) - sc-417152-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF146 CRISPR Activation Plasmid (h2) - sc-417152-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF146 Lentiviral Activation Particles (h) - sc-417152-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF146 Lentiviral Activation Particles (h2) - sc-417152-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF146 siRNA (h) - sc-95285 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF146 shRNA Plasmid (h) - sc-95285-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF146 shRNA (h) Lentiviral Particles - sc-95285-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF146 RNAi - H00081847-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU093171 from Sigma-Aldrich

Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN18390 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18390 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05747 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05747

RNF146 siRNA (Human) - CRJ3062 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNF146 - MBS8201253 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RNF146 (NM_030963.3) - SHH396808 from Creative biogene

Category siRNA
Species Reactivities Human

RNF146 shRNA Plasmid (Human) - CHJ3062 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RNF146 miRNA 3'UTR clone - MiUTR3H-12323 from Creative biogene

Species Reactivities Human
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