RNF146

Gene Symbol RNF146
Entrez Gene 81847
Alt Symbol dJ351K20.1
Species Human
Gene Type protein-coding
Description ring finger protein 146
Other Description 2610509H23Rik|E3 ubiquitin-protein ligase RNF146|dactylidin|iduna
Swissprots Q9NTX6 Q7L8H4 Q96T06 Q9NTX7 Q6FIB2 E1P572 Q96K03
Accessions EAW48109 EAW48110 EAW48111 EAW48112 EAW48113 Q9NTX7 AI929027 AJ315122 CAC85986 AJ420549 AK027436 BAB55108 AK027558 BAB55196 AK027776 BAB55359 AL136829 CAB66763 AM392718 CAL37596 AM393788 CAL38663 BC008235 AAH08235 BG708628 BI669435 BI771613 CN388414 CR533514 CAG38545 DA043259 DA145911 DA639989 DA707096 DA826982 DB267873 XM_006715571 XP_006715634 XM_011536161 XP_011534463 XM_011536162 XP_011534464 XM_011536163 XP_011534465 XM_011536164 XP_011534466 NM_001242847 NM_001242848 NM_001242844 NP_001229773 NM_001242845 NP_001229774 NM_001242846 NP_001229775 NM_001242849 NP_001229778 NM_001242850 NP_001229779 NM_001242851 NP_001229780 NM_001242852 NP_001229781 NM_030963 NP_112225 NR_045102 NR_045103
Function E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective prote
Subcellular Location Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus after DNA damage, such as laser- induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding.
Tissue Specificity Ubiquitously expressed. Up-regulated in brains from patients with Alzheimer disease.

Human RNF146 full length protein - ab153534 from Abcam

Category Protein
Source Wheat germ
Species Human
ab153534 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human RNF146 protein fragment - ab153535 from Abcam

Category Protein
Source Wheat germ
Species Human
ab153535 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Recombinant Human RNF146 Protein - H00081847-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

RNF146 Recombinant Protein - H00081847-P01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

RNF146 Blocking Peptide - 33R-1618 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

RNF146 - H00081847-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

RNF146 - H00081847-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

RNF146 - H00081847-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

RNF146 - H00081847-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

RNF146 fusion protein - ag15088 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

RNF146 fusion protein - ag14942 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human E3 ubiquitin-protein ligase RNF146(RNF146) - CSB-YP889110HU CSB-EP889110HU CSB-BP889110HU CSB-MP889110HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

RNF146 Recombinant Protein Antigen - NBP1-85319PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

RNF146 Recombinant Protein Antigen - NBP1-85318PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

RNF146 Peptide, Human - M34GP13391H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

E3 ubiquitin-protein ligase RNF146 (RNF146), Recombinant Protein - MBS1371672 from MyBioSource

Category Protein
Prices $1,125.00, $1,125.00, $1,355.00, $1,355.00, $1,785.00, $1,785.00, $2,250.00, $2,250.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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