Gene Symbol | HRSP12 |
---|---|
Entrez Gene | 10247 |
Alt Symbol | P14.5, PSP, UK114 |
Species | Human |
Gene Type | protein-coding |
Description | heat-responsive protein 12 |
Other Description | 14.5 kDa translational inhibitor protein|UK114 antigen homolog|perchloric acid-soluble protein|ribonuclease UK114|translational inhibitor p14.5|translational inhibitor protein p14.5 |
Swissprots | Q6IBG0 Q6FHU9 P52758 |
Accessions | AAK01939 CAJ42760 EAW91774 EAW91775 P52758 BC010280 AAH10280 BC012592 AAH12592 BC093059 AAH93059 BX348173 CR456844 CAG33125 CR541652 CAG46453 D62115 DQ892797 ABM83723 DQ896044 ABM87043 X95384 CAA64670 NM_005836 NP_005827 |
Function | Endoribonuclease responsible for the inhibition of the translation by cleaving mRNA. Inhibits cell-free protein synthesis. Cleaves phosphodiester bonds only in single-stranded RNA (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm. Nucleus. Note=Mostly cytoplasmic but, in less differentiated cells occasionally nuclear. |
Tissue Specificity | Hepatocytes and renal distal tubular epithelial cells. Only weak expression in other tissues. |