| Gene Symbol |
CPQ
|
| Entrez Gene |
10404
|
| Alt Symbol |
LDP, PGCP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
carboxypeptidase Q
|
| Other Description |
Ser-Met dipeptidase|aminopeptidase|blood plasma glutamate carboxypeptidase|lysosomal dipeptidase
|
| Swissprots |
B2RD88 Q9UNM8 Q9Y646 Q8NBZ1 Q9Y5X6
|
| Accessions |
EAW91757 EAW91758 Q9Y646 AA492294 AF107833 AAD43213 AF107834 AAD43214 AF119386 AAD31418 AK075132 BAC11423 AK296013 BAG58784 AK304008 BAG64924 AK315447 BAG37835 BC012019 BC020689 AAH20689 BF445505 DA699663 DQ893177 ABM84103 DQ896759 ABM87758 XM_005250755 XP_005250812 XM_006716498 XP_006716561 XM_011516793 XP_011515095 XM_011516794 XP_011515096 XR_428374 XR_928286 NM_016134 NP_057218
|
| Function |
Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.
|
| Subcellular Location |
Endoplasmic reticulum {ECO:0000269|PubMed:10206990}. Golgi apparatus {ECO:0000269|PubMed:10206990}. Lysosome {ECO:0000250}. Secreted {ECO:0000269|PubMed:10206990}. Note=Secretion is stimulated by TSH/thyroid-stimulating hormone, INS/insulin and SST/somatostatin. {ECO:0000250}.
|
| Tissue Specificity |
Mainly detected in blood plasma. Abundant in placenta and kidney. Present at low level in muscles, liver and skin fibroblasts. Not detected in brain or white blood cells (at protein level). {ECO:0000269|PubMed:10206990}.
|
![Western Blot: PGCP Overexpression Lysate (Adult Normal) [NBL1-14328] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PGCP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1316_PGCP%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14328-img0002.jpg)