Gene Symbol | PLA2G1B |
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Entrez Gene | 5319 |
Alt Symbol | PLA2, PLA2A, PPLA2 |
Species | Human |
Gene Type | protein-coding |
Description | phospholipase A2, group IB (pancreas) |
Other Description | phosphatidylcholine 2-acylhydrolase 1B|phospholipase A2 |
Swissprots | B2R4H5 Q3KPI1 P04054 |
Accessions | AAA60107 AAB95635 AAR05441 EAW98184 P04054 AA844927 AK311830 BAG34772 BC005386 AAH05386 BC013384 BC106725 AAI06726 BC106726 AAI06727 BE969737 BX113838 CA867923 EU832774 ACE87785 GQ129318 ACT64452 M21054 AAA36450 NM_000928 NP_000919 |
Function | PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. {ECO:0000269|PubMed:19297324}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:19297324}. Note=secreted from pancreatic acinar cells in its inactive form. |
Top Pathways | Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism |
group IB sPLA 2 CRISPR/Cas9 KO Plasmid (h) - sc-407667 from Santa Cruz Biotechnology
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group IB sPLA 2 HDR Plasmid (h) - sc-407667-HDR from Santa Cruz Biotechnology
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group IB sPLA 2 Double Nickase Plasmid (h) - sc-407667-NIC from Santa Cruz Biotechnology
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group IB sPLA 2 Double Nickase Plasmid (h2) - sc-407667-NIC-2 from Santa Cruz Biotechnology
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group IB sPLA 2 CRISPR Activation Plasmid (h) - sc-407667-ACT from Santa Cruz Biotechnology
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group IB sPLA 2 CRISPR Activation Plasmid (h2) - sc-407667-ACT-2 from Santa Cruz Biotechnology
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group IB sPLA 2 Lentiviral Activation Particles (h) - sc-407667-LAC from Santa Cruz Biotechnology
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group IB sPLA 2 Lentiviral Activation Particles (h2) - sc-407667-LAC-2 from Santa Cruz Biotechnology
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group IB sPLA 2 siRNA (h) - sc-96105 from Santa Cruz Biotechnology
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group IB sPLA 2 shRNA Plasmid (h) - sc-96105-SH from Santa Cruz Biotechnology
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group IB sPLA 2 shRNA (h) Lentiviral Particles - sc-96105-V from Santa Cruz Biotechnology
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PLA2G1B RNAi - H00005319-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN16887 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16887 from Sigma-Aldrich
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PLA2G1B siRNA (Human) - CRH3560 from Cohesion Biosciences
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shRNA set against Human PLA2G1B (NM_000928.2) - SHH376724 from Creative biogene
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shRNA set against Human PLA2G1B(NM_000928.2) - SHR118534 from Creative biogene
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PLA2G1B shRNA Plasmid (Human) - CHH3560 from Cohesion Biosciences
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PLA2G1B miRNA 3'UTR clone - MiUTR1H-07955 from Creative biogene
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