| Gene Symbol | MLANA |
|---|---|
| Entrez Gene | 2315 |
| Alt Symbol | MART-1, MART1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | melan-A |
| Other Description | antigen LB39-AA|antigen SK29-AA|melanoma antigen recognized by T-cells 1|protein Melan-A |
| Swissprots | Q6ICU4 Q16655 |
| Accessions | CAC37866 CAD79827 EAW58755 EAW58756 Q16655 AK312149 BAG35083 BC014423 AAH14423 CR450299 CAG29295 DQ892257 ABM83183 DQ895459 ABM86385 U06452 AAA19238 U06654 AAA20389 NM_005511 NP_005502 |
| Function | Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. {ECO:0000269|PubMed:15695812, ECO:0000269|PubMed:19717472}. |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post- Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation. |
| Tissue Specificity | Expression is restricted to melanoma and melanocyte cell lines and retina. |
Melan-A CRISPR/Cas9 KO Plasmid (h) - sc-418014 from Santa Cruz Biotechnology
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Melan-A HDR Plasmid (h) - sc-418014-HDR from Santa Cruz Biotechnology
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Melan-A Double Nickase Plasmid (h) - sc-418014-NIC from Santa Cruz Biotechnology
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Melan-A Double Nickase Plasmid (h2) - sc-418014-NIC-2 from Santa Cruz Biotechnology
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Melan-A CRISPR Activation Plasmid (h) - sc-418014-ACT from Santa Cruz Biotechnology
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Melan-A CRISPR Activation Plasmid (h2) - sc-418014-ACT-2 from Santa Cruz Biotechnology
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Melan-A Lentiviral Activation Particles (h) - sc-418014-LAC from Santa Cruz Biotechnology
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Melan-A Lentiviral Activation Particles (h2) - sc-418014-LAC-2 from Santa Cruz Biotechnology
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Melan-A siRNA (h) - sc-35920 from Santa Cruz Biotechnology
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Melan-A shRNA Plasmid (h) - sc-35920-SH from Santa Cruz Biotechnology
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Melan-A shRNA (h) Lentiviral Particles - sc-35920-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU009801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14389 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14389 from Sigma-Aldrich
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MLANA siRNA (Human) - CRH1620 from Cohesion Biosciences
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shRNA set against Human MLANA (NM_005511.1) - SHH342392 from Creative biogene
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shRNA set against Human MLANA(NM_005511.1) - SHH191567 from Creative biogene
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MLANA shRNA Plasmid (Human) - CHH1620 from Cohesion Biosciences
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MLANA miRNA 3'UTR clone - MiUTR1H-06317 from Creative biogene
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