BLOC1S4
| Gene Symbol | BLOC1S4 |
|---|---|
| Entrez Gene | 55330 |
| Alt Symbol | BCAS4L, BLOS4, CNO |
| Species | Human |
| Gene Type | protein-coding |
| Description | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino |
| Other Description | BLOC-1 subunit 4|biogenesis of lysosome-related organelles complex 1 subunit 4|cappuccino homolog|protein cappuccino homolog |
| Swissprots | Q6NVY6 Q96G84 Q9NUP1 |
| Accessions | EAW82382 Q9NUP1 AF085849 AI679712 AK002092 BAA92080 BC001818 BC009890 BC067815 AAH67815 NM_018366 NP_060836 |
| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. {ECO:0000269|PubMed:17182842}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
CNO RNAi - H00055330-R01 from Novus Biologicals
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MISSION® esiRNA - EHU136441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6317 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6317 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06451 from Sigma-Aldrich
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BLOC1S4 siRNA (Human) - CRJ0662 from Cohesion Biosciences
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BLOC1S4 - MBS829298 from MyBioSource
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shRNA set against Human CNO (NM_018366.2) - SHH266389 from Creative biogene
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shRNA set against Human CNO(NM_018366.2) - SHG187513 from Creative biogene
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BLOC1S4 shRNA Plasmid (Human) - CHJ0662 from Cohesion Biosciences
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BLOC1S4 miRNA 3'UTR clone - MiUTR1H-02278 from Creative biogene
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