| Gene Symbol |
MYH10
|
| Entrez Gene |
4628
|
| Alt Symbol |
NMMHC-IIB, NMMHCB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
myosin, heavy chain 10, non-muscle
|
| Other Description |
cellular myosin heavy chain, type B|myosin heavy chain, nonmuscle type B|myosin, heavy polypeptide 10, non-muscle|myosin-10|nonmuscle myosin II heavy chain-B|nonmuscle myosin heavy chain IIB
|
| Swissprots |
Q6PK16 P35580 Q4LE45 Q16087 Q149N4 Q149N3 F8VTL3 Q12989 Q9BWG0 B2RWP9 D3DTS1
|
| Accessions |
AAC50619 AAC50620 EAW90046 EAW90047 EAW90048 EAW90049 EAW90050 P35580 AB210026 BAE06108 AB621820 BAK64156 AF086505 AK026977 BC000280 AAH00280 BC008968 AAH08968 BC117690 AAI17691 BC117691 AAI17692 BC144668 AAI44669 BC150634 AAI50635 BE799557 BG421687 BG723653 BU173337 CA443268 DA737414 DQ925667 ABL59894 M69181 AAA99177 S67247 AAB28952 U15618 AAA87712 U34304 AAA84880 XM_005256651 XP_005256708 XM_011523875 XP_011522177 XM_011523876 XP_011522178 XM_011523877 XP_011522179 XM_011523878 XP_011522180 XM_011523879 XP_011522181 XM_011523880 XP_011522182 NM_001256012 NP_001242941 NM_001256095 NP_001243024 NM_005964 NP_005955
|
| Function |
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.
|
| Subcellular Location |
Cell projection, lamellipodium {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:22480440}. Note=Colocalizes with MCC at the leading edge of migrating cells.
|
| Tissue Specificity |
Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum. {ECO:0000269|PubMed:7782316}.
|
| Top Pathways |
Tight junction, Salmonella infection, Regulation of actin cytoskeleton
|