| Gene Symbol |
PDE7A
|
| Entrez Gene |
5150
|
| Alt Symbol |
HCP1, PDE7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphodiesterase 7A
|
| Other Description |
TM22|high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A|phosphodiesterase isozyme 7
|
| Swissprots |
A0AVH6 A8K9G5 Q13946 A8K436 O15380 Q96T72
|
| Accessions |
CAD29836 CAV30707 CBX54286 CBX54287 CDL93463 CDL96991 EAW86883 EAW86884 EAW86885 EAW86886 Q13946 AF332652 AAK57640 AI632383 AK057586 AK290801 BAF83490 AK292680 BAF85369 AW387924 AY266364 AAP31236 BC058025 BC126360 AAI26361 BM818331 CN414361 DB146108 DB460103 DR000686 HG501292 HQ258418 ADR83172 N49050 U67932 AAB65772 XM_011517540 XP_011515842 NM_001242318 NP_001229247 NM_002603 NP_002594 NM_002604
|
| Function |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. {ECO:0000269|PubMed:19350606}.
|
| Subcellular Location |
Isoform PDE7A1: Cytoplasm, cytosol. Note=PDE7A1 (57 kDa) is located mostly to soluble cellular fractions.
|
| Tissue Specificity |
PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart.
|
| Top Pathways |
Morphine addiction, Purine metabolism
|
![Western Blot: PDE7A Overexpression Lysate (Adult Normal) [NBP2-08091] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PDE7A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/14549_PDE7A%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-08091-img0001.jpg)
![Western Blot: PDE7A Overexpression Lysate (Adult Normal) [NBL1-14230] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PDE7A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3252_PDE7A%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14230-img0002.jpg)