Gene Symbol | PDE7A |
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Entrez Gene | 5150 |
Alt Symbol | HCP1, PDE7 |
Species | Human |
Gene Type | protein-coding |
Description | phosphodiesterase 7A |
Other Description | TM22|high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A|phosphodiesterase isozyme 7 |
Swissprots | A0AVH6 A8K9G5 Q13946 A8K436 O15380 Q96T72 |
Accessions | CAD29836 CAV30707 CBX54286 CBX54287 CDL93463 CDL96991 EAW86883 EAW86884 EAW86885 EAW86886 Q13946 AF332652 AAK57640 AI632383 AK057586 AK290801 BAF83490 AK292680 BAF85369 AW387924 AY266364 AAP31236 BC058025 BC126360 AAI26361 BM818331 CN414361 DB146108 DB460103 DR000686 HG501292 HQ258418 ADR83172 N49050 U67932 AAB65772 XM_011517540 XP_011515842 NM_001242318 NP_001229247 NM_002603 NP_002594 NM_002604 |
Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. {ECO:0000269|PubMed:19350606}. |
Subcellular Location | Isoform PDE7A1: Cytoplasm, cytosol. Note=PDE7A1 (57 kDa) is located mostly to soluble cellular fractions. |
Tissue Specificity | PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart. |
Top Pathways | Morphine addiction, Purine metabolism |
Active human PDE7A protein fragment - ab125786 from Abcam
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Active human PDE7A protein fragment - ab79740 from Abcam
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Active mouse PDE7A protein fragment - ab198756 from Abcam
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Active rat PDE7A protein fragment - ab198419 from Abcam
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Human PDE7A full length protein - ab152598 from Abcam
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Human PDE7A protein fragment - ab152599 from Abcam
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PDE7A Antibody Blocking Peptide - LS-E4738 from LifeSpan Bioscience
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PDE7A Antibody Blocking Peptide - LS-E23488 from LifeSpan Bioscience
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PDE7A Antibody Blocking Peptide - LS-E23487 from LifeSpan Bioscience
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PDE7A Antibody Blocking Peptide - LS-E29215 from LifeSpan Bioscience
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Recombinant Human PDE7A Protein - H00005150-Q01 from Novus Biologicals
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Recombinant Human PDE7A Protein - H00005150-P01 from Novus Biologicals
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PDE7A-Antibody-N-term-Blocking-Peptide - BP17110a from Abgent, a WuXi AppTec company
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PDE7A - H00005150-P01 from Acris Antibodies
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PDE7A - H00005150-Q01-10 from Acris Antibodies
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PDE7A - H00005150-Q01-25 from Acris Antibodies
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PDE7A Control Peptide - AP10247CP-N from Acris Antibodies
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PDE7A fusion protein - Ag16253 from Proteintech Group
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PDE7A fusion protein - Ag24474 from Proteintech Group
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PDE7A fusion protein - ag17717 from Proteintech Group
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PDE7A, Active Human Recombinant Protein - GWB-2500BE from Genway Biotech
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Recombinant Human Phosphodiesterase 7A, GST-tagged, Active - PDE7A-481H from Creative Biomart
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Recombinant Human PDE7A, GST-tagged - PDE7A-1606H from Creative Biomart
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Recombinant Human PDE7A - PDE7A-332H from Creative Biomart
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Recombinant Human PDE7A (Active), GST-tagged - PDE7A-1531H from Creative Biomart
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