| Gene Symbol |
KPNA3
|
| Entrez Gene |
3839
|
| Alt Symbol |
IPOA4, SRP1, SRP1gamma, SRP4, hSRP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
karyopherin alpha 3 (importin alpha 4)
|
| Other Description |
SRP1-gamma|importin alpha 4|importin alpha Q2|importin alpha-3|importin subunit alpha-3|importin subunit alpha-4|importin-alpha-Q2|karyopherin subunit alpha-3|qip2
|
| Swissprots |
O00191 O00505 Q96AA7 Q5JVM9 O43195
|
| Accessions |
EAX08837 EAX08838 EAX08839 O00505 AF005263 AAQ13404 AF034756 AAB87693 AI309735 AK223480 BAD97200 AK290528 BAF83217 AK291000 BAF83689 AU132188 BC017355 AAH17355 BC024202 AAH24202 BC035090 AAH35090 D89618 BAA20378 DN991804 DQ892644 ABM83570 DQ895882 ABM86808 Y12394 CAA73026 NM_002267 NP_002258
|
| Function |
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably thro
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous. Highest levels in heart and skeletal muscle.
|