KPNA3

Gene Symbol KPNA3
Entrez Gene 3839
Alt Symbol IPOA4, SRP1, SRP1gamma, SRP4, hSRP1
Species Human
Gene Type protein-coding
Description karyopherin alpha 3 (importin alpha 4)
Other Description SRP1-gamma|importin alpha 4|importin alpha Q2|importin alpha-3|importin subunit alpha-3|importin subunit alpha-4|importin-alpha-Q2|karyopherin subunit alpha-3|qip2
Swissprots O00191 O00505 Q96AA7 Q5JVM9 O43195
Accessions EAX08837 EAX08838 EAX08839 O00505 AF005263 AAQ13404 AF034756 AAB87693 AI309735 AK223480 BAD97200 AK290528 BAF83217 AK291000 BAF83689 AU132188 BC017355 AAH17355 BC024202 AAH24202 BC035090 AAH35090 D89618 BAA20378 DN991804 DQ892644 ABM83570 DQ895882 ABM86808 Y12394 CAA73026 NM_002267 NP_002258
Function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably thro
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity Ubiquitous. Highest levels in heart and skeletal muscle.

karyopherin α3 (B-1) - sc-514101 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
karyopherin α3 (B-1): sc-514101. Western blot analysis of karyopherin α3 expression in A-673 whole cell lysate.

QIP1 (L-13) - sc-55268 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-KPNA3 antibody - ab84706 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human KPNA3 by Immunohistochemistry.Sample: FFPE section of Human ovarian carcinoma.Antibody: ab84706 used at a dilution of 1/250.Detection: DAB staining.

Anti-KPNA3 antibody - ab105348 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-KPNA3 antibody (ab105348) at 1 µg/mlLane 2 : Anti-KPNA3 antibody (ab105348) at 2 µg/mlLane 1 : EL4 cell lysateLane 2 : EL4 cell lysateLysates/proteins at 15 µg per lane.

Anti-KPNA3 antibody - ab117578 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of KPNA3 expression in Formalin-Fixed, Paraffin-Embedded Human Adrenal using 5 µg/ml ab117578.

Anti-KPNA3 antibody - ab81453 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-KPNA3 antibody (ab81453) at 1 µg/ml (in 5% skim milk / PBS buffer) + MCF7 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-KPNA3 antibody - C-terminal - ab194366 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Anti-KPNA3 antibody - C-terminal (ab194366) at 1/500 dilution + IMR-32 cell lysate at 50 µg

Anti-KPNA3 / Importin Alpha 4 Antibody (N-Terminus) - LS-C81901 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MCF7 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-KPNA3 / Importin Alpha 4 Antibody (clone 3D10) - LS-C179426 from LifeSpan Bioscience

Prices $370.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 3D10

Anti-KPNA3 / Importin Alpha 4 Antibody (aa1-50) - LS-C288414 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human KPNA3 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-KPNA3 used at a dilution of 1:200 (1 Detection: DAB.

Anti-KPNA3 / Importin Alpha 4 Antibody (aa1-50) - LS-C286559 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Mouse KPNA3 by Immunohistochemistry. Sample: FFPE section of mouse teratoma. Antibody: Affinity purified rabbit anti-KPNA3 used at a dilution of 1:250.

Anti-KPNA3 / Importin Alpha 4 Antibody (aa509-521) IHC-plus™ - LS-B2289 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-KPNA3 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2289 concentration 5 ug/ml.

Anti-KPNA3 / Importin Alpha 4 Antibody (C-Terminus) IHC-plus™ - LS-B5341 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KPNA3 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5341 concentration 5 ug/ml.

KPNA3 Antibody - NB100-81650 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: KPNA3 Antibody [NB100-81650] - Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 mcg) cells. NB100-81650 used for WB at 0.4 mcg/ml (A and B) and used for IP at 3 mcg/mg lysate.

KPNA3 Antibody - NB100-1373 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: KPNA3 Antibody [NB100-1373] - Staining (0.1ug/ml) of Human Testis lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

KPNA3 Antibody - NBP1-52976 from Novus Biologicals

Prices $139.00, $299.00
Sizes 20 µl, 50 µl
Host Rabbit
Clonality Polyclonal
Western Blot: KPNA3 Antibody [NBP1-52976] - Human Fetal Lung, Antibody Dilution: 1.0 ug/ml.

KPNA3 Antibody - NBP1-31031 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: KPNA3 Antibody [NBP1-31031] - Sample(30 ug of whole cell lysate)A:293TB:A431 C:H129910% SDS PAGE, antibody diluted at 1:1500.

KPNA3 Antibody - NBP2-17088 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: KPNA3 Antibody [NBP2-17088] - Sample (30 ug of whole cell lysate) A: HCT116 7. 5% SDS PAGE gel, diluted at 1:2000.

KPNA3 Antibody - H00003839-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: KPNA3 Antibody [H00003839-A01] - KPNA3 polyclonal antibody (A01), Lot # FAK0060120QCS1 Western Blot analysis of KPNA3 expression in IMR-32 ( Cat # L008V1 ).

Anti-KPNA3 antibody produced in rabbit - SAB2101292 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-KPNA3: <B>Cat. No.SAB2101292</B>: KPNA3 in MCF7 cell lysate with KPNA3 antibody at 1.0 μg/mL.

Anti-KPNA3 (1-14) antibody produced in rabbit - SAB1100045 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-KPNA3 (1-14), <B>Cat. No. SAB1100045</B>: Immunofluorescence of HUVEC cells using Anti-KPNA3 (1-14), SAB1100045 (red), taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-KPNA3 antibody produced in rabbit - HPA046852 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-KPNA3:<B>Cat. No. HPA046852</B>: Immunohistochemical staining of human heart muscle shows moderate nuclear positivity in myocytes.

Anti-KPNA3 (501-515) antibody produced in rabbit - SAB1100046 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-KPNA3 (501-515), <B>Cat. No. SAB1100046</B>: Immunofluorescence of HUVEC cells using Anti-KPNA3 (501-515), SAB1100046 (red), taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-KPNA3 antibody produced in rabbit - SAB3500561 from Sigma-Aldrich

Prices $346.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-KPNA3: <B>Cat. No. SAB3500561</B>: KPNA3 in EL4 cell lysate with KPNA3 antibody at (A) 1 and (B) 2 μg/mL.

Anti-KPNA3/IPOA4 antibody produced in goat - SAB2500574 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-KPNA3 / IPOA4: <B>Cat. No. SAB2500574</B>: staining (0.1 μg/mL) of Human Testis lysate (RIPA buffer, 35 μg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
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