| Gene Symbol |
RMI2
|
| Entrez Gene |
116028
|
| Alt Symbol |
BLAP18, C16orf75
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RecQ mediated genome instability 2
|
| Other Description |
BLM-associated protein of 18 kDa|RMI2, RecQ mediated genome instability 2, homolog|recQ-mediated genome instability protein 2
|
| Swissprots |
Q8TBL0 B3KVZ6 Q49AE2 Q96E14
|
| Accessions |
EAW85155 Q96E14 AK123764 BAG53958 BC013040 AAH13040 BC022427 AAH22427 BC031016 AAH31016 BC039361 AAH39361 CN311350 NM_152308 NP_689521 NR_130754
|
| Function |
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. The complex is therefore essential for the stability, localization, and function of complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress- induced nuclear foci and mitotic phosphorylation of BLM. {ECO:0000269|PubMed:18923082, ECO:0000269|PubMed:18923083}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:18923082}. Note=Colocalizes with BLM at nuclear DNA repair foci.
|
| Top Pathways |
Fanconi anemia pathway
|