| Gene Symbol |
CARD17
|
| Entrez Gene |
440068
|
| Alt Symbol |
INCA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
caspase recruitment domain family, member 17
|
| Other Description |
Inhibitory CARD|caspase recruitment domain-containing protein 17|caspase-1 inhibitor INCA|inhibitory caspase recruitment domain (CARD) protein|inhibitory caspase recruitment domain protein
|
| Swissprots |
Q5XLA6
|
| Accessions |
EAW67064 Q5XLA6 AY761064 AAV28630 BC146363 AAI46364 XM_011542838 XP_011541140 NM_001007232 NP_001007233
|
| Function |
Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation. {ECO:0000269|PubMed:15383541}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:15383541}.
|