Gene Symbol | CARD17 |
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Entrez Gene | 440068 |
Alt Symbol | INCA |
Species | Human |
Gene Type | protein-coding |
Description | caspase recruitment domain family, member 17 |
Other Description | Inhibitory CARD|caspase recruitment domain-containing protein 17|caspase-1 inhibitor INCA|inhibitory caspase recruitment domain (CARD) protein|inhibitory caspase recruitment domain protein |
Swissprots | Q5XLA6 |
Accessions | EAW67064 Q5XLA6 AY761064 AAV28630 BC146363 AAI46364 XM_011542838 XP_011541140 NM_001007232 NP_001007233 |
Function | Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation. {ECO:0000269|PubMed:15383541}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:15383541}. |
CARD 17 CRISPR/Cas9 KO Plasmid (h) - sc-418094 from Santa Cruz Biotechnology
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CARD 17 HDR Plasmid (h) - sc-418094-HDR from Santa Cruz Biotechnology
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CARD 17 Double Nickase Plasmid (h) - sc-418094-NIC from Santa Cruz Biotechnology
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CARD 17 Double Nickase Plasmid (h2) - sc-418094-NIC-2 from Santa Cruz Biotechnology
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CARD 17 CRISPR Activation Plasmid (h) - sc-418094-ACT from Santa Cruz Biotechnology
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CARD 17 CRISPR Activation Plasmid (h2) - sc-418094-ACT-2 from Santa Cruz Biotechnology
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CARD 17 Lentiviral Activation Particles (h) - sc-418094-LAC from Santa Cruz Biotechnology
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CARD 17 Lentiviral Activation Particles (h2) - sc-418094-LAC-2 from Santa Cruz Biotechnology
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CARD 17 siRNA (h) - sc-105576 from Santa Cruz Biotechnology
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CARD 17 shRNA Plasmid (h) - sc-105576-SH from Santa Cruz Biotechnology
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CARD 17 shRNA (h) Lentiviral Particles - sc-105576-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN5365 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5365 from Sigma-Aldrich
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CARD17 siRNA (Human) - CRJ8231 from Cohesion Biosciences
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CARD17 - MBS8240410 from MyBioSource
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shRNA set against Human CARD17 (NM_001007232.1) - SHH254705 from Creative biogene
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Human CARD17 siRNA - orb278732 from Biorbyt
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CARD17 shRNA Plasmid (Human) - CHJ8231 from Cohesion Biosciences
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CARD17 miRNA 3'UTR clone - MiUTR1H-04941 from Creative biogene
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