| Gene Symbol |
DOCK2
|
| Entrez Gene |
1794
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dedicator of cytokinesis 2
|
| Other Description |
dedicator of cyto-kinesis 2|dedicator of cytokinesis protein 2
|
| Swissprots |
Q2M3I0 Q96AK7 Q92608
|
| Accessions |
EAW61491 EAW61492 Q92608 AK128107 BAG54631 AK128449 BAG54676 AK130744 BAC85420 BC016996 AAH16996 BC035613 BC084556 AAH84556 BC104900 AAI04901 BC113457 AAI13458 BC143358 BF110460 D86964 BAA13200 DB145764 XM_005265830 XP_005265887 XM_011534448 XP_011532750 XM_011534449 XP_011532751 XM_011534450 XP_011532752 XM_011534451 XP_011532753 XR_941089 NM_004946 NP_004937
|
| Function |
Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}.
|
| Subcellular Location |
Endomembrane system {ECO:0000269|PubMed:12393632}; Peripheral membrane protein {ECO:0000269|PubMed:12393632}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12393632}. Note=Colocalizes with F-actin.
|
| Tissue Specificity |
Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon. {ECO:0000269|PubMed:10559471}.
|
| Top Pathways |
Fc gamma R-mediated phagocytosis, Chemokine signaling pathway
|