DOCK2

Gene Symbol DOCK2
Entrez Gene 1794
Alt Symbol -
Species Human
Gene Type protein-coding
Description dedicator of cytokinesis 2
Other Description dedicator of cyto-kinesis 2|dedicator of cytokinesis protein 2
Swissprots Q2M3I0 Q96AK7 Q92608
Accessions EAW61491 EAW61492 Q92608 AK128107 BAG54631 AK128449 BAG54676 AK130744 BAC85420 BC016996 AAH16996 BC035613 BC084556 AAH84556 BC104900 AAI04901 BC113457 AAI13458 BC143358 BF110460 D86964 BAA13200 DB145764 XM_005265830 XP_005265887 XM_011534448 XP_011532750 XM_011534449 XP_011532751 XM_011534450 XP_011532752 XM_011534451 XP_011532753 XR_941089 NM_004946 NP_004937
Function Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}.
Subcellular Location Endomembrane system {ECO:0000269|PubMed:12393632}; Peripheral membrane protein {ECO:0000269|PubMed:12393632}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12393632}. Note=Colocalizes with F-actin.
Tissue Specificity Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon. {ECO:0000269|PubMed:10559471}.
Top Pathways Fc gamma R-mediated phagocytosis, Chemokine signaling pathway

DOCK 2 (E-7) - sc-365242 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DOCK 2 (E-7): sc-365242. Western blot analysis of DOCK 2 expression in Jurkat whole cell lysate.

DOCK 2 (E-15) - sc-50921 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

DOCK 2 (H-99) - sc-99070 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

DOCK 2 (Q-16) - sc-50923 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-DOCK2 antibody - ab74659 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-DOCK2 antibody (ab74659) at 2 µg/ml + Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate at 20 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-DOCK2 antibody - ab203068 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed and paraffin embedded mouse intestine labeling DOCK2 using ab203068 at 1/200 dilution. DAB staining.

Anti-DOCK2 antibody - ab64449 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-DOCK2 antibody (ab64449) at 1 µg/ml + Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-DOCK2 antibody - ab199871 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-DOCK2 antibody (ab199871) at 1/1000 dilutionLane 1 : Mouse thymus total cell extractLane 2 : Jurkat total cell extract

Anti-DOCK2 antibody [7G2] - ab180405 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7G2
All lanes : Anti-DOCK2 antibody [7G2] (ab180405) at 1/2000 dilutionLane 1 : Non-transfected HEK293T cellLane 2 : DOCK2-transfected HEK293T cellLysates/proteins at 5 µg per lane.

Anti-DOCK2 antibody [EPR6647] - ab124838 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6647
All lanes : Anti-DOCK2 antibody [EPR6647] (ab124838) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : Raji cell lysateLysates/proteins at 10 µg per lane.

Anti-DOCK2 Antibody (aa1544-1830, clone 7G2) - LS-C336633 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7G2
IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-DOCK2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-DOCK2 Antibody (Internal) - LS-C125478 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DOCK2 Antibody (aa420-642) - LS-C128657 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-DOCK2 Antibody (clone 2F4) - LS-C197070 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F4

Anti-DOCK2 Antibody - LS-C311093 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DOCK2 Antibody (C-Terminus) - LS-C107732 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DOCK2 antibody LS-C107732 Western blot of THP-1 cell lysate.

Anti-DOCK2 Antibody (C-Terminus, clone EPR6647) - LS-C138933 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6647
IHC of paraffin-embedded human lung tissue using anti-DOCK2 antibody. Note. Positive staining of peripheral lymphocytes

Anti-DOCK2 Antibody (aa1544-1830, clone 4E12) - LS-C338585 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4E12
IHC of paraffin-embedded Human lymph node tissue using anti-DOCK2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

DOCK2 Antibody - AF5339 from Novus Biologicals

Prices $99.00, $329.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of Jurkat human acute T cell leukemia cell line, HeLa human cervical epithelial carcinoma cell line, and Raji human Burkitt's lymphoma cell line. PVDF Membrane was probed with 1 µg/mL of Goat Anti-Human DOCK2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5339) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for DOCK2 at approximately 190 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

DOCK2 Antibody - NBP2-38303 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DOCK2 Antibody [NBP2-38303] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10Lane 2: Human cell line HL-60

DOCK2 Antibody - NBP1-83023 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: DOCK2 Antibody [NBP1-83023] - Immunofluorescent staining of human cell line A-431 shows positivity in nucleus but not nucleoli, plasma membrane & cytoplasm. Antibody staining is shown in green.

DOCK2 Antibody - NBP1-58870 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: DOCK2 Antibody [NBP1-58870] - THP-1 cell lysate, concentration 0.2-1 ug/ml.

DOCK2 Antibody (2F4) - H00001794-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F4
Proximity Ligation Assay: DOCK2 Antibody (2F4) [H00001794-M01] - Analysis of protein-protein interactions between CD247 and DOCK2. HeLa cells were stained with anti-CD247 rabbit purified polyclonal 1:1200 and anti-DOCK2 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).

DOCK2 Polyclonal Antibody - bs-12431R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded mouse intestine labeled with Anti-DOCK2 Polyclonal Antibody, Unconjugated (bs-12431R) at 1:200 followed by conjugation to the secondary antibody and DAB staining\\n

DOCK2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12431R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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