DOCK2

Gene Symbol	DOCK2
Entrez Gene	1794
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	dedicator of cytokinesis 2
Other Description	dedicator of cyto-kinesis 2|dedicator of cytokinesis protein 2
Swissprots	Q2M3I0 Q96AK7 Q92608
Accessions	EAW61491 EAW61492 Q92608 AK128107 BAG54631 AK128449 BAG54676 AK130744 BAC85420 BC016996 AAH16996 BC035613 BC084556 AAH84556 BC104900 AAI04901 BC113457 AAI13458 BC143358 BF110460 D86964 BAA13200 DB145764 XM_005265830 XP_005265887 XM_011534448 XP_011532750 XM_011534449 XP_011532751 XM_011534450 XP_011532752 XM_011534451 XP_011532753 XR_941089 NM_004946 NP_004937
Function	Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}.
Subcellular Location	Endomembrane system {ECO:0000269|PubMed:12393632}; Peripheral membrane protein {ECO:0000269|PubMed:12393632}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12393632}. Note=Colocalizes with F-actin.
Tissue Specificity	Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon. {ECO:0000269|PubMed:10559471}.
Top Pathways	Fc gamma R-mediated phagocytosis, Chemokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DOCK2 full length protein - ab132560 from Abcam Category Protein Source Wheat germ Species Human

Human DOCK2 peptide - ab74657 from Abcam Category Peptide

Human DOCK2 peptide - ab74658 from Abcam Category Peptide

DOCK2 Antibody Blocking Peptide - LS-E18683 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DOCK2 Protein - H00001794-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DOCK2 Blocking Peptide - 33R-1320 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DOCK2 - H00001794-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DOCK2 - H00001794-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DOCK2 fusion protein - ag3246 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Dedicator Of Cytokinesis 2 (DOCK2) - RPG182Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Dedicator Of Cytokinesis 2 (DOCK2) - RPG182Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Dedicator of cytokinesis protein 2(DOCK2) ,partial - CSB-YP849772HU CSB-EP849772HU CSB-BP849772HU CSB-MP849772HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Dedicator Of Cytokinesis 2 Protein (Recombinant) - abx166509 from Abbexa Category Protein Source Human Species Human

DOCK2 Protein - NBP1-83023PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

DOCK2 Protein - NBP2-38303PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

DOCK2-Blocking-Peptide-C-term - BP21150a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DOCK2 Peptide, Human - M34GP04474H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Dedicator Of Cytokinesis 2 (DOCK2) - RPU51615 from Biomatik Category Protein Prices $176.00, $360.00, $550.00, $656.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

DOCK2 Recombinant Protein (OPCD02779) - OPCD02779 from Aviva Systems Biology Category Protein Source E.coli Species Human

Dedicator Of Cytokinesis 2, Recombinant Protein - MBS2030185 from MyBioSource Category Protein Prices $175.00, $360.00, $560.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Dedicator of cytokinesis protein 2 (DOCK2), partial, Recombinant Protein - MBS1372911 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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