WWC1

Gene Symbol	WWC1
Entrez Gene	23286
Alt Symbol	HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168
Species	Human
Gene Type	protein-coding
Description	WW and C2 domain containing 1
Other Description	HBeAg-binding protein 3|WW, C2 and coiled-coil domain containing 1|kidney and brain protein|protein KIBRA|protein WWC1|protein phosphatase 1, regulatory subunit 168
Swissprots	Q6MZX4 Q8IX03 O94946 Q6Y2F8 Q9BT29 B4DK05 Q7Z4G8 Q8WVM4
Accessions	CCQ43496 CDM21935 CDM22293 EAW61508 EAW61509 EAW61510 Q8IX03 AB020676 BAA74892 AF506799 AAO15881 AF530058 AAQ09942 AK001727 AK027022 AK126376 BAG54317 AK296323 BAG59017 AY189820 AAO73817 BC004394 AAH04394 BC017746 AAH17746 BC038463 BC042553 AAH42553 BC156527 AAI56528 BC172519 AAI72519 BX640827 CAE45903 CA313640 DR001014 XM_005265850 XP_005265907 XM_005265853 XP_005265910 XM_011534485 XP_011532787 XM_011534486 XP_011532788 XM_011534487 XP_011532789 XM_011534488 XP_011532790 XM_011534489 XP_011532791 XM_011534490 XP_011532792 XM_011534491 XP_011532793 NM_001161661 NP_001155133 NM_001161662 NP_001155134 NM_015238 NP_056053
Function	Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance. {ECO:0000269|PubMed:15081397, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:23778582}.
Subcellular Location	Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell projection, ruffle membrane. Note=Colocalizes with PRKCZ in the perinuclear region.
Tissue Specificity	Expressed in mammary epithelial cells and breast cancer cell lines. Found in the luminal epithelium surrounding the ducts in the normal breast. In the brain, expressed in somatodendritic compartment of neurons in the cortex and hippocampus and in the cerebellum it is found in the Purkinje cells and some granule cells (at protein level). Detected in brain, heart, colon and kidney. In the kidney, expressed in glomerular podocytes, in some tubules and in the collecting duct. {ECO:0000269|PubMed:12559952, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031}.
Top Pathways	Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse WWC1 / KIBRA ELISA Kit (Sandwich ELISA) - LS-F8906 from LifeSpan Bioscience Category ELISA Kit Prices $810.00 Sizes 1 plate Sensitivity 30 pg/ml Range 78.13-5000 pg/ml

WW and C2 domain containing 1, ELISA Kit - MBS2603003 from MyBioSource Category ELISA Kit Prices $275.00, $420.00, $1,615.00, $2,880.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.06 ng/ml Range 20 ng/ml-0.312 ng/ml

ELISA Kit for Kidney And Brain Protein (KIBRA) - SEL824Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 30pg/mL. Range 78.13-5000pg/mL The standard curve concentrations used for the ELISA’s were 5000pg/mL, 2500pg/mL, 1250pg/mL, 625pg/mL, 312.5pg/mL, 156.25pg/mL, 78.13pg/mL

Human WWC1 / KIBRA ELISA Kit (Custom ELISA) - LS-F19824 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 78.13-5000 pg/ml

Mouse WWC1 / KIBRA ELISA Kit (Custom ELISA) - LS-F19823 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 78.13-5000 pg/ml

Human Protein KIBRA ELISA Kit - abx251599 from Abbexa Category ELISA Kit Range 78 pg/ml - 5000 pg/ml

Human Protein KIBRA ELISA Kit - EKE51999 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 32 pg/mL Range 78-5000 pg/mL

WWC1 - EKH4504 from Nordic BioSite Sensitivity 46.9pg/ml Range 78-5000pg/ml

WWC1 ELISA Kit (Human) (OKEH01685) - OKEH01685 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 32 pg/mL Range 78 - 5,000 pg/mL

Human WWC1 ELISA Kit - E021753 from Biobool Category ELISA Kit

Human Protein KIBRA ELISA Kit - EK4562 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Range 0.31 ng/mL -20.0 ng/mL

Protein KIBRA (WWC1), ELISA Kit - MBS2610538 from MyBioSource Category ELISA Kit Prices $300.00, $475.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein KIBRA, ELISA Kit - MBS2603261 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein KIBRA, ELISA Kit - MBS2606682 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein KIBRA , ELISA Kit - MBS2604132 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein KIBRA, ELISA Kit - MBS2606024 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

KIBRA, ELISA Kit - MBS288868 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 78.0 pg/mL -5000 pg/mL

KIBRA, ELISA Kit - MBS9428388 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Sensitivity Less than 32pg/mL Range 78-5000 pg/mL

Protein KIBRA, ELISA Kit - MBS760854 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 46.9pg/ml Range 78-5000pg/ml

Protein KIBRA, ELISA Kit - MBS2607340 from MyBioSource Category ELISA Kit Prices $275.00, $420.00, $1,615.00, $2,880.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein KIBRA, ELISA Kit - MBS2607452 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein KIBRA, ELISA Kit - MBS2607038 from MyBioSource Category ELISA Kit Prices $290.00, $450.00, $1,755.00, $3,150.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human WWC1 / KIBRA ELISA Kit (Sandwich ELISA) - LS-F34290 from LifeSpan Bioscience Category ELISA Kit Sensitivity 46.9 Range 78.13-5000 pg/ml

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