| Gene Symbol |
WWC1
|
| Entrez Gene |
23286
|
| Alt Symbol |
HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
WW and C2 domain containing 1
|
| Other Description |
HBeAg-binding protein 3|WW, C2 and coiled-coil domain containing 1|kidney and brain protein|protein KIBRA|protein WWC1|protein phosphatase 1, regulatory subunit 168
|
| Swissprots |
Q6MZX4 Q8IX03 O94946 Q6Y2F8 Q9BT29 B4DK05 Q7Z4G8 Q8WVM4
|
| Accessions |
CCQ43496 CDM21935 CDM22293 EAW61508 EAW61509 EAW61510 Q8IX03 AB020676 BAA74892 AF506799 AAO15881 AF530058 AAQ09942 AK001727 AK027022 AK126376 BAG54317 AK296323 BAG59017 AY189820 AAO73817 BC004394 AAH04394 BC017746 AAH17746 BC038463 BC042553 AAH42553 BC156527 AAI56528 BC172519 AAI72519 BX640827 CAE45903 CA313640 DR001014 XM_005265850 XP_005265907 XM_005265853 XP_005265910 XM_011534485 XP_011532787 XM_011534486 XP_011532788 XM_011534487 XP_011532789 XM_011534488 XP_011532790 XM_011534489 XP_011532791 XM_011534490 XP_011532792 XM_011534491 XP_011532793 NM_001161661 NP_001155133 NM_001161662 NP_001155134 NM_015238 NP_056053
|
| Function |
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance. {ECO:0000269|PubMed:15081397, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:23778582}.
|
| Subcellular Location |
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell projection, ruffle membrane. Note=Colocalizes with PRKCZ in the perinuclear region.
|
| Tissue Specificity |
Expressed in mammary epithelial cells and breast cancer cell lines. Found in the luminal epithelium surrounding the ducts in the normal breast. In the brain, expressed in somatodendritic compartment of neurons in the cortex and hippocampus and in the cerebellum it is found in the Purkinje cells and some granule cells (at protein level). Detected in brain, heart, colon and kidney. In the kidney, expressed in glomerular podocytes, in some tubules and in the collecting duct. {ECO:0000269|PubMed:12559952, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031}.
|
| Top Pathways |
Hippo signaling pathway
|