WWC1

Gene Symbol	WWC1
Entrez Gene	23286
Alt Symbol	HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168
Species	Human
Gene Type	protein-coding
Description	WW and C2 domain containing 1
Other Description	HBeAg-binding protein 3|WW, C2 and coiled-coil domain containing 1|kidney and brain protein|protein KIBRA|protein WWC1|protein phosphatase 1, regulatory subunit 168
Swissprots	Q6MZX4 Q8IX03 O94946 Q6Y2F8 Q9BT29 B4DK05 Q7Z4G8 Q8WVM4
Accessions	CCQ43496 CDM21935 CDM22293 EAW61508 EAW61509 EAW61510 Q8IX03 AB020676 BAA74892 AF506799 AAO15881 AF530058 AAQ09942 AK001727 AK027022 AK126376 BAG54317 AK296323 BAG59017 AY189820 AAO73817 BC004394 AAH04394 BC017746 AAH17746 BC038463 BC042553 AAH42553 BC156527 AAI56528 BC172519 AAI72519 BX640827 CAE45903 CA313640 DR001014 XM_005265850 XP_005265907 XM_005265853 XP_005265910 XM_011534485 XP_011532787 XM_011534486 XP_011532788 XM_011534487 XP_011532789 XM_011534488 XP_011532790 XM_011534489 XP_011532791 XM_011534490 XP_011532792 XM_011534491 XP_011532793 NM_001161661 NP_001155133 NM_001161662 NP_001155134 NM_015238 NP_056053
Function	Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance. {ECO:0000269|PubMed:15081397, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:23778582}.
Subcellular Location	Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell projection, ruffle membrane. Note=Colocalizes with PRKCZ in the perinuclear region.
Tissue Specificity	Expressed in mammary epithelial cells and breast cancer cell lines. Found in the luminal epithelium surrounding the ducts in the normal breast. In the brain, expressed in somatodendritic compartment of neurons in the cortex and hippocampus and in the cerebellum it is found in the Purkinje cells and some granule cells (at protein level). Detected in brain, heart, colon and kidney. In the kidney, expressed in glomerular podocytes, in some tubules and in the collecting duct. {ECO:0000269|PubMed:12559952, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031}.
Top Pathways	Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KIBRA full length protein - ab161587 from Abcam Category Protein Source Wheat germ Species Human

Human KIBRA protein fragment - ab177657 from Abcam Category Protein Source E. coli Species Human

WWC1 / KIBRA Antibody Blocking Peptide - LS-E457 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

WWC1 / KIBRA Antibody Blocking Peptide - LS-E23629 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KIBRA Recombinant Protein - H00023286-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

WWC1-Antibody-N-term-Blocking-peptide - BP10740a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

WWC1 protein (His tag) - 80R-3682 from Fitzgerald Category Protein Prices $375.00 Sizes 100 µg Source E.coli

WWC1 (655-783, His-tag) - AR51369PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 500 µg Source E. coli Species Human

WWC1 (655-783, His-tag) - AR51369PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

WWC1 - H00023286-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

WWC1 - H00023286-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

WWC1, 655-783aa, Human, His tag, E.coli - 01-P2549 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Species Human

WWC1 Peptide - 7991P from ProSci Category Peptide

WWC1, 655-783aa, Human, His tag, E.coli - GWB-ATG08D from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human WWC1, His-tagged - WWC1-5053H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human WW and C2 domain containing 1, His-tagged - WWC1-452H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Kidney And Brain Protein (KIBRA) - RPL824Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Kidney And Brain Protein (KIBRA) - RPL824Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Human Protein KIBRA(WWC1) ,partial - CSB-YP812885HU CSB-EP812885HU CSB-BP812885HU CSB-MP812885HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

WW And C2 Domain Containing 1 Protein (Recombinant) - abx261958 from Abbexa Category Protein

WWC1 - TP314592 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

WW And C2 Domain Containing 1, Recombinant Protein - MBS146207 from MyBioSource Category Protein Prices $140.00, $205.00, $3,465.00 Sizes 5 µg, 20 µg, 1 mg Source E Coli

WWC1, Recombinant Protein - MBS205538 from MyBioSource Category Protein Prices $375.00, $925.00 Sizes 100 µg, 500 µg Source E Coli Species Human

Human WWC1 protein - orb260164 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

KIBRA Recombinant Protein Antigen - NBP1-92053PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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