Gene Symbol | ARPC4 |
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Entrez Gene | 10093 |
Alt Symbol | ARC20, P20-ARC |
Species | Human |
Gene Type | protein-coding |
Description | actin related protein 2/3 complex, subunit 4, 20kDa |
Other Description | actin-related protein 2/3 complex subunit 4|arp2/3 complex 20 kDa subunit|arp2/3 protein complex subunit p20 |
Swissprots | Q6P0W5 F6TTL5 E7ETI0 C9JWM7 O15509 P59998 Q96QJ3 |
Accessions | EAW63998 EAW64001 P59998 AF006087 AAB64192 AF019888 AAB71548 AI612891 AK074205 AW408422 BC012596 AAH12596 BC065423 BC152790 AAI52791 BG938423 BI768875 BI910730 BM045872 BQ688329 BX419672 DA226584 DA909066 DB060690 NM_001024959 NP_001020130 NM_001024960 NP_001020131 NM_001198780 NP_001185709 NM_005718 NP_005709 |
Function | Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9359840}. Cell projection {ECO:0000269|PubMed:9359840}. |
Top Pathways | Pathogenic Escherichia coli infection, Fc gamma R-mediated phagocytosis, Bacterial invasion of epithelial cells, Salmonella infection, Regulation of actin cytoskeleton |
p20-ARC CRISPR/Cas9 KO Plasmid (h) - sc-405006 from Santa Cruz Biotechnology
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p20-ARC HDR Plasmid (h) - sc-405006-HDR from Santa Cruz Biotechnology
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p20-ARC Double Nickase Plasmid (h) - sc-405006-NIC from Santa Cruz Biotechnology
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p20-ARC Double Nickase Plasmid (h2) - sc-405006-NIC-2 from Santa Cruz Biotechnology
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p20-ARC CRISPR Activation Plasmid (h) - sc-405006-ACT from Santa Cruz Biotechnology
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p20-ARC CRISPR Activation Plasmid (h2) - sc-405006-ACT-2 from Santa Cruz Biotechnology
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p20-ARC Lentiviral Activation Particles (h) - sc-405006-LAC from Santa Cruz Biotechnology
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p20-ARC Lentiviral Activation Particles (h2) - sc-405006-LAC-2 from Santa Cruz Biotechnology
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p20-ARC siRNA (h) - sc-106339 from Santa Cruz Biotechnology
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p20-ARC shRNA Plasmid (h) - sc-106339-SH from Santa Cruz Biotechnology
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p20-ARC shRNA (h) Lentiviral Particles - sc-106339-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN3529 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3529 from Sigma-Aldrich
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ARPC4 siRNA (Human) - CRH6801 from Cohesion Biosciences
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ARPC4 - MBS8224684 from MyBioSource
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Human ARPC4 siRNA - orb267303 from Biorbyt
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ARPC4 shRNA Plasmid (Human) - CHH6801 from Cohesion Biosciences
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ARPC4 miRNA 3'UTR clone - MiUTR3H-06660 from Creative biogene
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ARPC4 miRNA 3'UTR clone - MiUTR3H-06661 from Creative biogene
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ARPC4 miRNA 3'UTR clone - MiUTR3H-06662 from Creative biogene
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