| Gene Symbol |
GLDC
|
| Entrez Gene |
2731
|
| Alt Symbol |
GCE, GCSP, HYGN1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glycine dehydrogenase (decarboxylating)
|
| Other Description |
glycine cleavage system protein P|glycine decarboxylase P-protein|glycine dehydrogenase (aminomethyl-transferring)|glycine dehydrogenase (decarboxylating), mitochondrial|glycine dehydrogenase [decarboxylating], mitochondrial
|
| Swissprots |
Q2M2F8 P23378
|
| Accessions |
AAK28443 EAW58739 EAW58740 P23378 AI480362 AK308470 AK310534 AK314156 BAG36841 AW593954 BC111993 AAI11994 BC111995 AAI11996 D90239 BAA14286 DA741442 DR002916 M63635 AAA36478 M64590 AAA36463 NM_000170 NP_000161
|
| Function |
The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).
|
| Subcellular Location |
Mitochondrion.
|
| Top Pathways |
Glycine, serine and threonine metabolism, Carbon metabolism
|