Gene Symbol | GLDC |
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Entrez Gene | 2731 |
Alt Symbol | GCE, GCSP, HYGN1 |
Species | Human |
Gene Type | protein-coding |
Description | glycine dehydrogenase (decarboxylating) |
Other Description | glycine cleavage system protein P|glycine decarboxylase P-protein|glycine dehydrogenase (aminomethyl-transferring)|glycine dehydrogenase (decarboxylating), mitochondrial|glycine dehydrogenase [decarboxylating], mitochondrial |
Swissprots | Q2M2F8 P23378 |
Accessions | AAK28443 EAW58739 EAW58740 P23378 AI480362 AK308470 AK310534 AK314156 BAG36841 AW593954 BC111993 AAI11994 BC111995 AAI11996 D90239 BAA14286 DA741442 DR002916 M63635 AAA36478 M64590 AAA36463 NM_000170 NP_000161 |
Function | The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH). |
Subcellular Location | Mitochondrion. |
Top Pathways | Glycine, serine and threonine metabolism, Carbon metabolism |
GLDC CRISPR/Cas9 KO Plasmid (h) - sc-403511 from Santa Cruz Biotechnology
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GLDC HDR Plasmid (h) - sc-403511-HDR from Santa Cruz Biotechnology
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GLDC Double Nickase Plasmid (h) - sc-403511-NIC from Santa Cruz Biotechnology
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GLDC Double Nickase Plasmid (h2) - sc-403511-NIC-2 from Santa Cruz Biotechnology
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GLDC CRISPR Activation Plasmid (h) - sc-403511-ACT from Santa Cruz Biotechnology
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GLDC CRISPR Activation Plasmid (h2) - sc-403511-ACT-2 from Santa Cruz Biotechnology
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GLDC Lentiviral Activation Particles (h) - sc-403511-LAC from Santa Cruz Biotechnology
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GLDC Lentiviral Activation Particles (h2) - sc-403511-LAC-2 from Santa Cruz Biotechnology
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GLDC siRNA (h) - sc-92873 from Santa Cruz Biotechnology
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GLDC shRNA Plasmid (h) - sc-92873-SH from Santa Cruz Biotechnology
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GLDC shRNA (h) Lentiviral Particles - sc-92873-V from Santa Cruz Biotechnology
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GLDC RNAi - H00002731-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN9335 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9335 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04709 from Sigma-Aldrich
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GLDC siRNA (Human) - CRH1816 from Cohesion Biosciences
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GLDC - MBS8217370 from MyBioSource
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shRNA set against Human Gldc (NM_000170.2) - SHH301690 from Creative biogene
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shRNA set against Human GLDC(NM_000170.2) - SHH086663 from Creative biogene
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Human GLDC siRNA - orb262318 from Biorbyt
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GLDC shRNA Plasmid (Human) - CHH1816 from Cohesion Biosciences
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GLDC miRNA 3'UTR clone - MiUTR1H-04058 from Creative biogene
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