| Gene Symbol |
RUNX3
|
| Entrez Gene |
864
|
| Alt Symbol |
AML2, CBFA3, PEBP2aC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
runt-related transcription factor 3
|
| Other Description |
CBF-alpha-3|PEA2 alpha C|PEA2-alpha C|PEBP2 alpha C|PEBP2-alpha C|SL3-3 enhancer factor 1 alpha C subunit|SL3/AKV core-binding factor alpha C subunit|acute myeloid leukemia 2 protein|acute myeloid leukemia gene 2|core-binding factor subunit alpha-3|core-binding factor, runt domain, alpha subunit 3|oncogene AML-2|polyomavirus enhancer-binding protein 2 alpha C subunit|transcription factor AML2
|
| Swissprots |
Q13760 B1AJV5 Q13761 Q12969
|
| Accessions |
AAA86465 CAB42882 CAH05600 CAR95149 CAR95150 CBX47510 CBX47511 EAW95147 EAW95148 EAW95149 Q13761 AF022726 AAB80759 AI375031 AJ001432 AK091829 AK300056 BAG61865 AK301044 BAG62657 AK310945 BC013362 AAH13362 DA935726 EF491807 EF491822 X79550 CAA56093 Z35278 CAA84541 XM_005246024 XP_005246081 XM_011542351 XP_011540653 NM_001031680 NP_001026850 NM_004350 NP_004341
|
| Function |
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00399, ECO:0000269|PubMed:20100835}. Cytoplasm {ECO:0000269|PubMed:20100835}. Note=The tyrosine phosphorylated form localizes to the cytoplasm.
|