RUNX3

Gene Symbol RUNX3
Entrez Gene 864
Alt Symbol AML2, CBFA3, PEBP2aC
Species Human
Gene Type protein-coding
Description runt-related transcription factor 3
Other Description CBF-alpha-3|PEA2 alpha C|PEA2-alpha C|PEBP2 alpha C|PEBP2-alpha C|SL3-3 enhancer factor 1 alpha C subunit|SL3/AKV core-binding factor alpha C subunit|acute myeloid leukemia 2 protein|acute myeloid leukemia gene 2|core-binding factor subunit alpha-3|core-binding factor, runt domain, alpha subunit 3|oncogene AML-2|polyomavirus enhancer-binding protein 2 alpha C subunit|transcription factor AML2
Swissprots Q13760 B1AJV5 Q13761 Q12969
Accessions AAA86465 CAB42882 CAH05600 CAR95149 CAR95150 CBX47510 CBX47511 EAW95147 EAW95148 EAW95149 Q13761 AF022726 AAB80759 AI375031 AJ001432 AK091829 AK300056 BAG61865 AK301044 BAG62657 AK310945 BC013362 AAH13362 DA935726 EF491807 EF491822 X79550 CAA56093 Z35278 CAA84541 XM_005246024 XP_005246081 XM_011542351 XP_011540653 NM_001031680 NP_001026850 NM_004350 NP_004341
Function CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00399, ECO:0000269|PubMed:20100835}. Cytoplasm {ECO:0000269|PubMed:20100835}. Note=The tyrosine phosphorylated form localizes to the cytoplasm.

RUNX3/AML2 (D9K6L) Mouse mAb - 13089 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone D9K6L
Western blot analysis of extracts from SW620, HT-1080, and MCF7 cells using RUNX3/AML2 (D9K6L) Mouse mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

RUNX3/AML2 (D6E2) Rabbit mAb - 9647 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6E2
Western blot analysis of extracts from SW620 and HeLa cells using RUNX3/AML2 (D6E2) Rabbit mAb.

RUNX3 (A-3) - sc-376591 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RUNX3 (A-3): sc-376591. Western blot analysis of RUNX3 expression in U266 whole cell lysate.

RUNX3 (B-9) - sc-376543 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RUNX3 (B0-9): sc-376543. Western blot analysis of RUNX3 expression in U266 whole cell lysate (A) and MEG-01 nuclear extract (B).

RUNX3 (R3-5G4) - sc-101553 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RUNX3 (R3-5G4): sc-101553. Western blot analysis of RUNX3 expression in MEG-01 nuclear extract (A) and U266 whole cell lysate (B).

RUNX3 (K-12) - sc-23576 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RUNX3 (H-50) - sc-30197 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-RUNX3 antibody - ab49117 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-RUNX3 antibody (ab49117) at 1.25 µg/ml + NIH3T3 cell lysate at 10 µg

Anti-RUNX3 antibody - ab83500 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RUNX3 antibody (ab83500) at 1 µg/mlLane 1 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate Lane 2 : RAW 264.7 (Mouse leukaemic monocyte macrophage cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-RUNX3 antibody [2B3] - ab135248 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B3
Flow cytometric analysis of NIH 3T3 cells labelling RUNX3 with ab135248 at 1/200 dilution (green). Negative control (red).

Anti-RUNX3 antibody [R3-5G4] - ab40278 from Abcam

Prices $390.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone R3-5G4
All lanes : Anti-RUNX3 antibody [R3-5G4] (ab40278) at 1 µg/mlLane 1 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate Lane 2 : Raji (Human Burkitt's lymphoma cell line) Whole Cell Lysate Lane 3 : SW480 (Human colon adenocarcinoma cell line) Whole Cell Lysate (ab3957)Lysates/proteins at 10 µg per lane.SecondaryIRDye 680 Conjugated Rabbit Anti-Mouse IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-RUNX3 antibody [R3-5G4] - BSA and Azide free - ab174769 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone R3-5G4

Anti-RUNX3 antibody - ChIP Grade - ab11905 from Abcam

Prices $384.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Detection of AML2 by EMSA analysis. Nushift polyclonal antibody against AML2 factor creates a supershift in EMSA (lane 4).

Anti-RUNX3 Antibody (aa168-197) - LS-C162814 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
RUNX3 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human stomach tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-RUNX3 Antibody (clone 2B3) IHC-plus™ - LS-B10743 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2B3
Anti-RUNX3 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10743 concentration 20 ug/ml.

Anti-RUNX3 Antibody - LS-C35989 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-RUNX3 Antibody - LS-C93417 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-RUNX3 Antibody (Internal) - LS-C94754 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-RUNX3 Antibody (Internal) - LS-C94759 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Sheep
Clonality Polyclonal

Anti-RUNX3 Antibody (aa186-415) - LS-C131971 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-RUNX3 Antibody - LS-C126242 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-RUNX3 Antibody (aa186-415, APC) - LS-C131972 from LifeSpan Bioscience

Prices $590.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal

Anti-RUNX3 Antibody (aa323-372) - LS-C30977 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
NIH 3T3 Cell Lysate

Anti-RUNX3 Antibody - LS-C150053 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-RUNX3 Antibody (clone 6821C3a) - LS-C184606 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 6821C3a
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