Gene Symbol | RUNX3 |
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Entrez Gene | 864 |
Alt Symbol | AML2, CBFA3, PEBP2aC |
Species | Human |
Gene Type | protein-coding |
Description | runt-related transcription factor 3 |
Other Description | CBF-alpha-3|PEA2 alpha C|PEA2-alpha C|PEBP2 alpha C|PEBP2-alpha C|SL3-3 enhancer factor 1 alpha C subunit|SL3/AKV core-binding factor alpha C subunit|acute myeloid leukemia 2 protein|acute myeloid leukemia gene 2|core-binding factor subunit alpha-3|core-binding factor, runt domain, alpha subunit 3|oncogene AML-2|polyomavirus enhancer-binding protein 2 alpha C subunit|transcription factor AML2 |
Swissprots | Q13760 B1AJV5 Q13761 Q12969 |
Accessions | AAA86465 CAB42882 CAH05600 CAR95149 CAR95150 CBX47510 CBX47511 EAW95147 EAW95148 EAW95149 Q13761 AF022726 AAB80759 AI375031 AJ001432 AK091829 AK300056 BAG61865 AK301044 BAG62657 AK310945 BC013362 AAH13362 DA935726 EF491807 EF491822 X79550 CAA56093 Z35278 CAA84541 XM_005246024 XP_005246081 XM_011542351 XP_011540653 NM_001031680 NP_001026850 NM_004350 NP_004341 |
Function | CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00399, ECO:0000269|PubMed:20100835}. Cytoplasm {ECO:0000269|PubMed:20100835}. Note=The tyrosine phosphorylated form localizes to the cytoplasm. |
RUNX3 CRISPR/Cas9 KO Plasmid (h) - sc-401377 from Santa Cruz Biotechnology
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RUNX3 HDR Plasmid (h) - sc-401377-HDR from Santa Cruz Biotechnology
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RUNX3 Double Nickase Plasmid (h) - sc-401377-NIC from Santa Cruz Biotechnology
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RUNX3 Double Nickase Plasmid (h2) - sc-401377-NIC-2 from Santa Cruz Biotechnology
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RUNX3 CRISPR Activation Plasmid (h) - sc-401377-ACT from Santa Cruz Biotechnology
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RUNX3 CRISPR Activation Plasmid (h2) - sc-401377-ACT-2 from Santa Cruz Biotechnology
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RUNX3 Lentiviral Activation Particles (h) - sc-401377-LAC from Santa Cruz Biotechnology
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RUNX3 Lentiviral Activation Particles (h2) - sc-401377-LAC-2 from Santa Cruz Biotechnology
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RUNX3 siRNA (h) - sc-37679 from Santa Cruz Biotechnology
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RUNX3 shRNA Plasmid (h) - sc-37679-SH from Santa Cruz Biotechnology
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RUNX3 shRNA (h) Lentiviral Particles - sc-37679-V from Santa Cruz Biotechnology
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RUNX3/CBFA3 RNAi - H00000864-R02 from Novus Biologicals
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RUNX3/CBFA3 RNAi - H00000864-R01 from Novus Biologicals
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MISSION® esiRNA - EHU135581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18759 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18759 from Sigma-Aldrich
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RUNX3 siRNA (Human) - CRH0609 from Cohesion Biosciences
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RUNX3 - MBS8207556 from MyBioSource
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shRNA set against Human RUNX3(NM_001031680.2) - SHR201890 from Creative biogene
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shRNA set against Human RUNX3(NM_004350.2) - SHR202062 from Creative biogene
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Human RUNX3 siRNA - orb261111 from Biorbyt
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RUNX3 shRNA Plasmid (Human) - CHH0609 from Cohesion Biosciences
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RUNX3 miRNA 3'UTR clone - MiUTR1H-09082 from Creative biogene
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