Gene Symbol | FBN1 |
---|---|
Entrez Gene | 2200 |
Alt Symbol | ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2 |
Species | Human |
Gene Type | protein-coding |
Description | fibrillin 1 |
Other Description | fibrillin 15|fibrillin-1 |
Swissprots | D2JYH6 B2RUU0 P35555 Q15972 Q75N87 |
Accessions | AAB25244 ACZ58372 BAD16737 BAD16738 BAD16739 CCQ42969 CCQ42970 EAW77353 EAW77354 P35555 AB208840 BAD92077 AK304737 BAG65498 AK309616 BC094721 BC146854 AAI46855 L13923 AAB02036 W81203 X62008 CAB56534 X63556 CAA45118 NM_000138 NP_000129 |
Function | Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. {ECO:0000269|PubMed:15062093}. |
Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:21989719}. |
fibrillin-1 CRISPR/Cas9 KO Plasmid (h) - sc-401449 from Santa Cruz Biotechnology
|
||||||||
fibrillin-1 HDR Plasmid (h) - sc-401449-HDR from Santa Cruz Biotechnology
|
||||||||
fibrillin-1 Double Nickase Plasmid (h) - sc-401449-NIC from Santa Cruz Biotechnology
|
||||||||
fibrillin-1 Double Nickase Plasmid (h2) - sc-401449-NIC-2 from Santa Cruz Biotechnology
|
||||||||
fibrillin-1 CRISPR Activation Plasmid (h) - sc-401449-ACT from Santa Cruz Biotechnology
|
||||||||
fibrillin-1 CRISPR Activation Plasmid (h2) - sc-401449-ACT-2 from Santa Cruz Biotechnology
|
||||||||
fibrillin-1 Lentiviral Activation Particles (h) - sc-401449-LAC from Santa Cruz Biotechnology
|
||||||||
fibrillin-1 Lentiviral Activation Particles (h2) - sc-401449-LAC-2 from Santa Cruz Biotechnology
|
||||||||
fibrillin-1 siRNA (h) - sc-43117 from Santa Cruz Biotechnology
|
||||||||
fibrillin-1 shRNA Plasmid (h) - sc-43117-SH from Santa Cruz Biotechnology
|
||||||||
fibrillin-1 shRNA (h) Lentiviral Particles - sc-43117-V from Santa Cruz Biotechnology
|
||||||||
Fibrillin 1 RNAi - H00002200-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU015751 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN8508 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8508 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR11670 from Sigma-Aldrich
|
||||||||
FBN1 siRNA (Human) - CRH1535 from Cohesion Biosciences
|
||||||||
FBN1 - MBS8222605 from MyBioSource
|
||||||||
shRNA set against Human FBN1 (NM_000138.4) - SHH292737 from Creative biogene
|
||||||||
Human FBN1 siRNA - orb262037 from Biorbyt
|
||||||||
FBN1 shRNA Plasmid (Human) - CHH1535 from Cohesion Biosciences
|