CBY1

Gene Symbol CBY1
Entrez Gene 25776
Alt Symbol C22orf2, CBY, HS508I15A, PGEA1, PIGEA-14, PIGEA14, arb1
Species Human
Gene Type protein-coding
Description chibby homolog 1 (Drosophila)
Other Description ARPP-binding protein|PKD2 interactor, Golgi and endoplasmic reticulum-associated 1|PKD2 interactor, golgi and endoplasmic reticulum associated 1|chibby CTNNB1-mediated transcription inhibitor|coiled-coil protein PIGEA-14|cytosolic leucine-rich protein|polycystin-2 interactor, Golgi- and endoplasmic reticulum-associated protein, 14 kDa|protein chibby homolog 1
Swissprots Q9UIK9 Q9Y3M2 B2R4S2 Q66GT6
Accessions DAA05582 EAW60254 EAW60255 EAW60256 Q9Y3M2 AB015347 BAA88119 AB111855 BAC78839 AF331041 AAL56062 AK307265 AK311928 BAG34869 AL050345 CAB43547 AL136686 CAB66621 AU099418 BC008839 BC016139 AAH16139 CD626926 CD702742 CR456410 CAG30296 HQ258005 ADR82759 NM_001002880 NP_001002880 NM_015373 NP_056188
Function Inhibits the Wnt/Wingless pathway by binding to beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. {ECO:0000269|PubMed:12712206, ECO:0000269|PubMed:15194699}.
Subcellular Location Nucleus speckle. Golgi apparatus, trans- Golgi network. Note=Nuclear, in a punctate manner. Also found in the trans-Golgi.
Tissue Specificity Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors. {ECO:0000269|PubMed:12712206}.

Chibby (FL-126) - sc-292137 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Chibby (M-127) - sc-292136 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Chibby (Y-12) - sc-86380 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Chibby (Y-12): sc-86380. Western blot analysis of mouse (A) and human (B) recombinant Chibby fusion proteins.

Chibby (S-13) - sc-86379 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Chibby (S-13): sc-86379. Western blot analysis of mouse (A) and human (B) recombinant Chibby fusion proteins.

Chibby (8-2) - sc-101551 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-PGEA1 antibody - ab87517 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-PGEA1 antibody - ab95100 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PGEA1 antibody (ab95100) at 1/100 dilution + MDA-MB231 cell line lysates at 35 µg

Anti-PGEA1 antibody - ab57020 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57020 PGEA1 antibody at 1ug/ml.

Anti-PGEA1 antibody - N-terminal - ab189607 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-PGEA1 antibody - N-terminal (ab189607) at 1/1000 dilution + HeLa total cell extract

Anti-CBY1 / PGEA1 Antibody (aa98-126) - LS-C165019 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human brain tissue reacted with HRIHFB2025 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-CBY1 / PGEA1 Antibody - LS-C309739 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

PGEA1 Antibody - NBP1-46303 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PGEA1 Antibody - H00025776-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: PGEA1 Antibody [H00025776-B01] - analysis of PGEA1 expression in transfected 293T cell line by PGEA1 MaxPab polyclonal antibody (B01). Lane 1: PGEA1 transfected lysate (14.50 KDa). Lane 2: Non-transfected lysate.

PGEA1 Antibody (2F2) - H00025776-M06 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F2
Western Blot: PGEA1 Antibody (2F2) [H00025776-M06] - Analysis of CBY1 expression in transfected 293T cell line by CBY1 monoclonal antibody (M06), clone 2F2. Lane 1: CBY1 transfected lysate (Predicted MW: 14.5 KDa). Lane 2: Non-transfected lysate.

PGEA1 Antibody - H00025776-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: PGEA1 Antibody [H00025776-D01P] - analysis of CBY1 expression in transfected 293T cell line by CBY1 MaxPab rabbit polyclonal antibody. Lane 1: CBY1 transfected lysate (14.50 KDa). Lane 2: Non-transfected lysate.

PGEA1 Antibody - H00025776-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

ANTI-HRIHFB2025 (C-TERM) antibody produced in rabbit - SAB1303542 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>HRIHFB2025 (C-term): <B>Cat. No. SAB1303542</B>: HRIHFB2025 in Human brain tissue with HRIHFB2025 antibody (C-term) at 5 μg/mL.

Anti-CBY1 antibody produced in rabbit - SAB1410473 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CBY1: <B>Cat. No. SAB1410473</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~14.5 kDa using CBY1 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-CBY1 antibody produced in rabbit - SAB4300812 from Sigma-Aldrich

Prices $230.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Monoclonal Anti-PGEA1 antibody produced in mouse - WH0025776M6 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F2
<B>Immunoblotting</B><BR/>Monoclonal Anti-PGEA1, <B>Cat. No. WH0025776M6</B> used at the antibody concentration: 1 μg/mL. Specific band of ~36.1 kDa using immunogen protein lysate.

HRIHFB2025-Antibody-C-term - AP9148b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of HRIHFB2025 Antibody (C-term) (Cat. #AP9148b) in MDA-MB231 cell line lysates (35ug/lane). HRIHFB2025 (arrow) was detected using the purified Pab.

PGEA1-Antibody-monoclonal-M06 - AT3280a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F2
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.73 KDa) .
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