| Gene Symbol | CBY1 |
|---|---|
| Entrez Gene | 25776 |
| Alt Symbol | C22orf2, CBY, HS508I15A, PGEA1, PIGEA-14, PIGEA14, arb1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chibby homolog 1 (Drosophila) |
| Other Description | ARPP-binding protein|PKD2 interactor, Golgi and endoplasmic reticulum-associated 1|PKD2 interactor, golgi and endoplasmic reticulum associated 1|chibby CTNNB1-mediated transcription inhibitor|coiled-coil protein PIGEA-14|cytosolic leucine-rich protein|polycystin-2 interactor, Golgi- and endoplasmic reticulum-associated protein, 14 kDa|protein chibby homolog 1 |
| Swissprots | Q9UIK9 Q9Y3M2 B2R4S2 Q66GT6 |
| Accessions | DAA05582 EAW60254 EAW60255 EAW60256 Q9Y3M2 AB015347 BAA88119 AB111855 BAC78839 AF331041 AAL56062 AK307265 AK311928 BAG34869 AL050345 CAB43547 AL136686 CAB66621 AU099418 BC008839 BC016139 AAH16139 CD626926 CD702742 CR456410 CAG30296 HQ258005 ADR82759 NM_001002880 NP_001002880 NM_015373 NP_056188 |
| Function | Inhibits the Wnt/Wingless pathway by binding to beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. {ECO:0000269|PubMed:12712206, ECO:0000269|PubMed:15194699}. |
| Subcellular Location | Nucleus speckle. Golgi apparatus, trans- Golgi network. Note=Nuclear, in a punctate manner. Also found in the trans-Golgi. |
| Tissue Specificity | Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors. {ECO:0000269|PubMed:12712206}. |