PTPRQ

Gene Symbol PTPRQ
Entrez Gene 374462
Alt Symbol DFNB84, DFNB84A, PTPGMC1, R-PTP-Q
Species Human
Gene Type protein-coding
Description protein tyrosine phosphatase, receptor type, Q
Other Description phosphatidylinositol phosphatase PTPRQ|phosphotidylinositol phosphatase PTPRQ|protein-tyrosine phosphatase, receptor-type, expressed by glomerular mesangial cells
Swissprots Q9UMZ3
Accessions Q9UMZ3 AF169351 AAD50277 BM750287 DA545412 DB305536 DB318211 DB341961 DN831929 DV080144 DV080238 DV080465 DV080607 DV080649 DV080650 DV080661 DW009832 DW009898 DW009906 DY655367 EG327664 XM_011538290 XP_011536592 NM_001145026 NP_001138498
Function Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells. {ECO:0000269|PubMed:19351528}.
Subcellular Location Membrane {ECO:0000269|PubMed:12837292}; Single-pass type I membrane protein {ECO:0000269|PubMed:12837292}.
Tissue Specificity In developing kidney, it localizes to the basal membrane of podocytes, beginning when podocyte progenitors can first be identified in the embryonic kidney (at protein level). Expressed in lung and kidney. {ECO:0000269|PubMed:12837292, ECO:0000269|PubMed:20346435}.

PTPRQ (C-20) - sc-32465 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PTPRQ (H-92) - sc-368569 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PTPRQ (H-92): sc-368569. Western blot analysis of PTPRQ expression in HEK293 (A) and SJRH30 (B) whole cell lysates and mouse skeletal muscle tissue extract (C).

Anti-PTPRQ antibody - ab185336 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin embedded Human kidney tissue labeling PTPRQ with ab185336 at 1/50 dilution.

PTPRQ Antibody - NBP2-31012 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: PTPRQ Antibody [NBP2-31012] - Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in tubular cells.

Anti-PTPRQ antibody produced in rabbit - HPA053245 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PTPRQ: <B>Cat. No. HPA053245</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in tubular cells.

Anti-PTPRQ antibody produced in chicken - GW21559 from Sigma-Aldrich

Host Chicken
Clonality Polyclonal

Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) - MAD603Hu21 from Uscn Life Science Inc.

Host Mouse
Clonality Monoclonal

Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type Q (PTPRQ) - PAD603Hu01 from Uscn Life Science Inc.

Host Rabbit
Clonality Polyclonal
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