MEP1B

Gene Symbol	MEP1B
Entrez Gene	4225
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	meprin A, beta
Other Description	N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta|N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit|PABA peptide hydrolase|PPH beta|endopeptidase-2|meprin A subunit beta|meprin B
Swissprots	Q16820 B7ZM35 Q670J1 B9EGL6
Accessions	EAX01284 EAX01285 Q16820 AY695931 AAU05377 BC136559 AAI36560 BC144244 AAI44245 X81333 CAA57107 XM_005258275 XP_005258332 XM_011526013 XP_011524315 XM_011526014 XP_011524316 NM_001308171 NP_001295100 NM_005925 NP_005916
Function	Membrane metallopeptidase that sheds many membrane-bound proteins. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. {ECO:0000269|PubMed:21693781}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Secreted. Note=Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17.
Tissue Specificity	The major site of expression is the brush border membrane of small intestinal and kidney epithelial cells. {ECO:0000269|PubMed:12387727}.
Top Pathways	Protein digestion and absorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Meprin beta peptide - ab44813 from Abcam Category Peptide

Meprin beta peptide - ab44825 from Abcam Category Peptide

Meprin beta peptide - ab44829 from Abcam Category Peptide

Meprin beta peptide - ab44833 from Abcam Category Peptide

Recombinant Human Meprin beta Subunit/MEP1B, CF - 2895-ZN-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Leu21-Ser593 & Thr23-Ser593, both with a C-terminal 10-His tag

Human Endopeptidase 2 protein - orb84000 from Biorbyt Category Protein Prices $323.00, $527.00 Sizes 10 μg, 20 μg Source Human Species Human

Human MEP1B (His Tag) protein - orb232246 from Biorbyt Category Protein Prices $400.00, $816.00 Sizes 10 μg, 50 μg Species Human

Recombinant Human Meprin A, Beta, His-tagged - MEP1B-1980H from Creative Biomart Category Protein Source Murine myeloma cellline, NS0-derived.

Recombinant Human MEP1B, His-tagged - MEP1B-562H from Creative Biomart Category Protein Source NSO Cells Species Human

Recombinant Meprin A Beta (MEP1b) - RPA173Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Meprin A Beta (MEP1b) - RPA173Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Human MEP1B / Meprin beta Protein (ECD, His Tag) - 10708-H08H-10 from Sino Biological Category Protein Prices $178.00, $448.00 Sizes 10 µg, 50 µg Source Human Cells Species Human

Recombinant Meprin A Beta (MEP1b) - RPA173Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Meprin A subunit beta(MEP1B) - CSB-YP618098HU CSB-EP618098HU CSB-BP618098HU CSB-MP618098HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Meprin beta Subunit/MEP1B Protein, CF - 2895-ZN from R&D Systems Category Protein Prices $299.00 Sizes 10 µg Source Mouse myeloma cell line, NS0-derived Leu21-Ser593 & Thr23-Ser593, both with a C-terminal 10-His tag Species Human

Recombinant Human MEP1B Protein, His-tagged - MEP1B-246H from Creative Biomart Category Protein Source HEK293 Species Human

Meprin beta Subunit/MEP1B Recombinant Protein Antigen - NBP2-37865PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MEP1B Peptide, Human - M34GP09406H from Creative Peptides Category Peptide Source Synthetic. Species Human

Mep1b, mouse recombinant - P1041-10 from Biovision Category Protein Prices $495.00 Sizes 10 μg Source Baculovirus Species Mouse

Meprin beta Subunit/MEP1B Recombinant Protein - NBP2-52323 from Novus Biologicals Category Protein Prices $259.00 Sizes 10 µg Source Baculovirus Species Mouse

Mep1b, mouse recombinant - P1041 from Biovision Category Protein Prices $495.00 Sizes 10 μg Source Baculovirus Species Mouse

Mep1b, Recombinant Protein - MBS846969 from MyBioSource Category Protein Prices $550.00 Sizes 10 µg Source Baculovirus Source: Mouse

Meprin A Beta, Recombinant Protein - MBS2031676 from MyBioSource Category Protein Prices $200.00, $430.00, $665.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Rat

Meprin A subunit beta (MEP1B), Recombinant Protein - MBS1487738 from MyBioSource Category Protein Prices $1,425.00, $1,425.00, $1,655.00, $1,655.00, $2,415.00, $2,415.00, $2,860.00, $2,860.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human Meprin beta Subunit/MEP1B Protein, CF - 2895-ZN from Novus Biologicals Category Protein Prices $299.00 Sizes 10 µg Species Human

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