| Gene Symbol |
MEP1B
|
| Entrez Gene |
4225
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
meprin A, beta
|
| Other Description |
N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta|N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit|PABA peptide hydrolase|PPH beta|endopeptidase-2|meprin A subunit beta|meprin B
|
| Swissprots |
Q16820 B7ZM35 Q670J1 B9EGL6
|
| Accessions |
EAX01284 EAX01285 Q16820 AY695931 AAU05377 BC136559 AAI36560 BC144244 AAI44245 X81333 CAA57107 XM_005258275 XP_005258332 XM_011526013 XP_011524315 XM_011526014 XP_011524316 NM_001308171 NP_001295100 NM_005925 NP_005916
|
| Function |
Membrane metallopeptidase that sheds many membrane-bound proteins. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. {ECO:0000269|PubMed:21693781}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Secreted. Note=Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17.
|
| Tissue Specificity |
The major site of expression is the brush border membrane of small intestinal and kidney epithelial cells. {ECO:0000269|PubMed:12387727}.
|
| Top Pathways |
Protein digestion and absorption
|
