MEP1B

Gene Symbol	MEP1B
Entrez Gene	4225
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	meprin A, beta
Other Description	N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta|N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit|PABA peptide hydrolase|PPH beta|endopeptidase-2|meprin A subunit beta|meprin B
Swissprots	Q16820 B7ZM35 Q670J1 B9EGL6
Accessions	EAX01284 EAX01285 Q16820 AY695931 AAU05377 BC136559 AAI36560 BC144244 AAI44245 X81333 CAA57107 XM_005258275 XP_005258332 XM_011526013 XP_011524315 XM_011526014 XP_011524316 NM_001308171 NP_001295100 NM_005925 NP_005916
Function	Membrane metallopeptidase that sheds many membrane-bound proteins. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. {ECO:0000269|PubMed:21693781}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Secreted. Note=Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17.
Tissue Specificity	The major site of expression is the brush border membrane of small intestinal and kidney epithelial cells. {ECO:0000269|PubMed:12387727}.
Top Pathways	Protein digestion and absorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Meprin Aβ (D-20) - sc-23491 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Meprin beta antibody - ab42743 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Meprin beta antibody - ab42733 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Meprin beta antibody - ab42740 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Meprin beta antibody - ab42744 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Meprin beta antibody [MM0811-31D21] - ab201933 from Abcam Prices $359.00 Sizes 100 µg Host Rat Clonality Monoclonal Clone MM0811-31D21

Anti-MEP1B Antibody - LS-C314419 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Meprin beta Subunit/MEP1B Antibody (289731) - MAB28951 from Novus Biologicals Prices $99.00, $249.00 Sizes 25 µg, 100 µg Host Rat Clonality Monoclonal Clone 289731

Meprin beta Subunit/MEP1B Antibody [Unconjugated] - AF2895 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

Meprin beta Subunit/MEP1B Antibody (289703) - Pro form - MAB28952 from Novus Biologicals Prices $99.00, $249.00 Sizes 25 µg, 100 µg Host Rat Clonality Monoclonal Clone 289703

Meprin beta Subunit/MEP1B Antibody - NBP2-37865 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Meprin beta Subunit/MEP1B Antibody - NB100-75322 from Novus Biologicals Prices $399.00 Sizes 50 µg Host Chicken Clonality Polyclonal

Meprin beta Subunit/MEP1B Antibody [Biotin] - BAF2895 from Novus Biologicals Prices $390.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-MEP1b antibody produced in chicken - GW21535 from Sigma-Aldrich Prices $267.50 Sizes 50 µg Host Chicken Clonality Polyclonal

MEP1B antibody - GTX82173 from GeneTex Prices $339.00 Sizes 50 μg Host Chicken Clonality Polyclonal

Mouse Meprin beta Subunit/MEP1B Antibody - AF3300 from R&D Systems Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat

Mouse Meprin beta Subunit Affinity Purified Polyclonal Ab, Goat IgG - AF3300-SP from R&D Systems Host Goat Clonality Polyclonal

Human Pro Meprin beta Subunit/MEP1B Antibody - MAB28952 from R&D Systems Prices $99.00, $249.00 Sizes 25 µg, 100 µg Host Rat Clone 289703

Human Pro-Meprin beta Subunit/MEP1B MAb (Clone 289703), Rat IgG2A - MAB28952-SP from R&D Systems Host Rat Clonality Monoclonal Clone 289703

Human/Mouse Meprin beta Subunit/MEP1B Antibody - MAB28951 from R&D Systems Prices $99.00, $249.00 Sizes 25 µg, 100 µg Host Rat Clone 289731

Human/Mouse Meprin beta Subunit/MEP1B MAb (Clone 289731), Rat IgG1 - MAB28951-SP from R&D Systems Host Rat Clonality Monoclonal Clone 289731

Human Meprin beta Subunit/MEP1B Antibody - AF2895 from R&D Systems Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat

Human Meprin beta Subunit Affinity Purified Polyclonal Ab, Goat IgG - AF2895-SP from R&D Systems Host Goat Clonality Polyclonal

Human Meprin beta Subunit/MEP1B Biotinylated Antibody - BAF2895 from R&D Systems Prices $390.00 Sizes 50 µg Host Goat

MEP1B Antibody - XW-7849 from ProSci Prices $325.00 Sizes 50 µg Host Chicken Clonality Polyclonal

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