Gene Symbol | PPP3R1 |
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Entrez Gene | 5534 |
Alt Symbol | CALNB1, CNB, CNB1 |
Species | Human |
Gene Type | protein-coding |
Description | protein phosphatase 3, regulatory subunit B, alpha |
Other Description | calcineurin B, type I (19kDa)|calcineurin subunit B type 1|protein phosphatase 2B regulatory subunit 1|protein phosphatase 2B regulatory subunit B alpha|protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)|protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)|protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform |
Swissprots | B2RC10 P63098 Q53SL0 B5MDU4 |
Accessions | AAY14715 EAW99878 P63098 AK307136 AK314893 BAG37407 BC027913 AAH27913 BM468705 BQ228635 CR456938 CAG33219 NM_000945 NP_000936 |
Function | Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}. Cell membrane, sarcolemma. Note=Translocates from the cytosol to the sarcolemma in a CIB1- dependent manner during cardiomyocytes hypertrophy. {ECO:0000250}. |
Top Pathways | Glucagon signaling pathway, Tuberculosis, Glutamatergic synapse, Amphetamine addiction, Oxytocin signaling pathway |
PP2B-B1 CRISPR/Cas9 KO Plasmid (h) - sc-406093 from Santa Cruz Biotechnology
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PP2B-B1 HDR Plasmid (h) - sc-406093-HDR from Santa Cruz Biotechnology
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PP2B-B1 Double Nickase Plasmid (h) - sc-406093-NIC from Santa Cruz Biotechnology
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PP2B-B1 Double Nickase Plasmid (h2) - sc-406093-NIC-2 from Santa Cruz Biotechnology
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PP2B-B1 CRISPR Activation Plasmid (h) - sc-406093-ACT from Santa Cruz Biotechnology
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PP2B-B1 CRISPR Activation Plasmid (h2) - sc-406093-ACT-2 from Santa Cruz Biotechnology
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PP2B-B1 Lentiviral Activation Particles (h) - sc-406093-LAC from Santa Cruz Biotechnology
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PP2B-B1 Lentiviral Activation Particles (h2) - sc-406093-LAC-2 from Santa Cruz Biotechnology
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PP2B-B1 siRNA (h) - sc-39199 from Santa Cruz Biotechnology
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PP2B-B1 shRNA Plasmid (h) - sc-39199-SH from Santa Cruz Biotechnology
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PP2B-B1 shRNA (h) Lentiviral Particles - sc-39199-V from Santa Cruz Biotechnology
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Calcineurin B RNAi - H00005534-R02 from Novus Biologicals
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MISSION® esiRNA - EHU100521 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0660 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0659 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0658 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17307 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17307 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11050 from Sigma-Aldrich
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PPP3R1 siRNA (Human) - CRH3713 from Cohesion Biosciences
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shRNA set against Human PPP3R1 (NM_000945.3) - SHH381568 from Creative biogene
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shRNA set against Human PPP3R1(NM_000945.3) - SHR135714 from Creative biogene
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Human PPP3R1 siRNA - orb264215 from Biorbyt
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PPP3R1 shRNA Plasmid (Human) - CHH3713 from Cohesion Biosciences
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PPP3R1 miRNA 3'UTR clone - MiUTR1H-08196 from Creative biogene
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