PRDX1
| Gene Symbol | PRDX1 |
|---|---|
| Entrez Gene | 5052 |
| Alt Symbol | MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | peroxiredoxin 1 |
| Other Description | natural killer cell-enhancing factor A|natural killer-enhancing factor A|peroxiredoxin-1|proliferation-associated gene A|proliferation-associated gene protein|thioredoxin peroxidase 2|thioredoxin-dependent peroxide reductase 2 |
| Swissprots | Q5T155 Q2V576 B5BU26 Q06830 D3DPZ8 P35703 Q5T154 |
| Accessions | ABB84465 CAH59516 EAX06975 EAX06976 EAX06977 EAX06978 EAX06979 EAX06980 EAX06981 EAX06982 Q06830 AB451262 BAG70076 AB451388 BAG70202 AI912389 AK131049 AK311898 BAG34839 AV691526 BC007063 AAH07063 BC021683 AAH21683 BM740381 BM762399 BM787105 BM827394 BT019740 AAV38545 BU564066 CD638470 CR407652 CAG28580 DQ893173 ABM84099 DQ896472 ABM87471 L19184 AAA50464 X67951 CAA48137 NM_001202431 NP_001189360 NM_002574 NP_002565 NM_181696 NP_859047 NM_181697 NP_859048 |
| Function | Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Top Pathways | Peroxisome |
PRX I CRISPR/Cas9 KO Plasmid (h) - sc-418249 from Santa Cruz Biotechnology
|
||||||||
PRX I HDR Plasmid (h) - sc-418249-HDR from Santa Cruz Biotechnology
|
||||||||
PRX I Double Nickase Plasmid (h) - sc-418249-NIC from Santa Cruz Biotechnology
|
||||||||
PRX I Double Nickase Plasmid (h2) - sc-418249-NIC-2 from Santa Cruz Biotechnology
|
||||||||
PRX I CRISPR Activation Plasmid (h) - sc-418249-ACT from Santa Cruz Biotechnology
|
||||||||
PRX I CRISPR Activation Plasmid (h2) - sc-418249-ACT-2 from Santa Cruz Biotechnology
|
||||||||
PRX I Lentiviral Activation Particles (h) - sc-418249-LAC from Santa Cruz Biotechnology
|
||||||||
PRX I Lentiviral Activation Particles (h2) - sc-418249-LAC-2 from Santa Cruz Biotechnology
|
||||||||
PRX I siRNA (h) - sc-36177 from Santa Cruz Biotechnology
|
||||||||
Pag shRNA Plasmid (h) - sc-36177-SH from Santa Cruz Biotechnology
|
||||||||
Pag shRNA (h) Lentiviral Particles - sc-36177-V from Santa Cruz Biotechnology
|
||||||||
PRX siRNA (h) - sc-37151 from Santa Cruz Biotechnology
|
||||||||
PRX shRNA Plasmid (h) - sc-37151-SH from Santa Cruz Biotechnology
|
||||||||
PRX shRNA (h) Lentiviral Particles - sc-37151-V from Santa Cruz Biotechnology
|
||||||||
Peroxiredoxin 1 RNAi - H00005052-R01 from Novus Biologicals
|
||||||||
Peroxiredoxin 1 RNAi - H00005052-R03 from Novus Biologicals
|
||||||||
Peroxiredoxin 1 RNAi - H00005052-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU111751 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN17382 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17382 from Sigma-Aldrich
|
||||||||
PRDX1 siRNA (Human) - CRH3358 from Cohesion Biosciences
|
||||||||
shRNA set against Human PRDX1 (NM_002574.3) - SHH382300 from Creative biogene
|
||||||||
Human PRDX1 siRNA - orb263860 from Biorbyt
|
||||||||
PRDX1 shRNA Plasmid (Human) - CHH3358 from Cohesion Biosciences
|
||||||||
PRDX1 miRNA 3'UTR clone - MiUTR3H-01839 from Creative biogene
|