Ntrk1

Gene Symbol	Ntrk1
Entrez Gene	59109
Alt Symbol	Trk
Species	Rat
Gene Type	protein-coding
Description	neurotrophic tyrosine kinase, receptor, type 1
Other Description	TrkA neurotrophin receptor|high affinity nerve growth factor receptor|p140-TrkA|slow nerve growth factor receptor|trk|trk-A|trkA proto-oncogene receptor|tropomyosin-related kinase A
Swissprots	P35739
Accessions	EDM00771 EDM00772 P35739 AF174586 AAF77635 AF174587 AAF77636 M85214 AAA42286 XM_006232746 XP_006232808 NM_021589 NP_067600
Function	Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras- PI3 kin
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Early endosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes.
Tissue Specificity	Isoform Trka-II is primarily expressed in neuronal cells; isoform Trka-I is found in non-neuronal tissues.
Top Pathways	Central carbon metabolism in cancer, Apoptosis, Inflammatory mediator regulation of TRP channels, Endocytosis, Neurotrophin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TrkA Rat ELISA Kit - ab119609 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 10 pg/ml Range 156 pg/ml - 10000 pg/ml

High affinity nerve growth factor receptor, Ntrk1, Rat, ELISA Kit - E9557r from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t

Neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), Rat, ELISA Kit - CSB-E17824r from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

TRK A, Rat, ELISA Kit - BEK1219 from ARP American Research Products Category ELISA Kit Prices $629.00 Sizes 96 t Sensitivity < 10pg/ml Range 156 pg/ml-10,000 pg/ml

Ntrk1 (Rat) ELISA Kit - KA1507 from Acris Antibodies Category ELISA Kit Prices $650.00 Sizes 1 kit

Rat TrkA ELISA Kit - GWB-ZZD196 from Genway Biotech Category ELISA Kit Prices $660.00 Sizes 1x96 well plate Range 156pg/ml-10000pg/ml. Test has a sensitivity of < 10 pg/ml

Ntrk1 (Rat) ELISA Kit - DEIA4003 from Creative Diagnostics Category ELISA Kit Range 156pg/mL-10000pg/mL

neurotrophic tyrosine kinase, receptor, type 1 (NTRK1) , ELISA Kit - MBS909985 from MyBioSource Category ELISA Kit Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

TRK A, ELISA Kit - MBS824745 from MyBioSource Category ELISA Kit Prices $470.00 Sizes 96 tests Sensitivity 10 pg/ml Range 156 pg/ml - 10000 pg/ml

TrkA, ELISA Kit - MBS175980 from MyBioSource Category ELISA Kit Prices $475.00 Sizes 1x96 wells Sensitivity < 10pg/ml Range 156pg/ml-10,000pg/ml

Rat TrkA ELISA Kit (1 plate) - BEK-2201-1P from Biosensis Category ELISA Kit Prices $398.50 Sizes 1 kit Sensitivity < 10pg/ml Range 156 pg/ml - 10,000 pg/ml

Rat TrkA ELISA Kit (2 plates) - BEK-2201-2P from Biosensis Category ELISA Kit Prices $797.00 Sizes 1 kit Sensitivity < 10pg/ml Range 156 pg/ml - 10,000 pg/ml

Rat TRK A ELISA Kit - CEK1640 from Cohesion Biosciences Category ELISA Kit Prices $360.00 Sizes 96 t Sensitivity 10 pg/ml Range 156 pg/ml - 10000 pg/ml

Rat TrkA PicoKine™ ELISA Kit EK0847 - EK0847 from Boster Bio Category ELISA Kit Prices $420.00 Sizes 1 kit Sensitivity <10pg/ml Range 156pg/ml-10000pg/ml *This assay range is determined using common samples. For samples with low target protein concentrations, users can adjust the standard curve to extend the lower limit of assay range.

Rat neurotrophic tyrosine kinase, receptor, type 1 (NTRK1) ELISA kit - CSB-E17824r from Cusabio Category ELISA Kit Sensitivity Request Information Range Request Information

Rat High affinity nerve growth factor receptor ELISA Kit - abx255643 from Abbexa Category ELISA Kit

Rat TRK A ELISA kit - abx050224 from Abbexa Category ELISA Kit Sensitivity < 10 pg/ml Range 156 pg/ml - 10000 pg/ml

NTRK1 - KBB-518 from Nordic BioSite Sensitivity <10pg/ml Range 156pg/ml-10000pg/ml

Rat TrkA ELISA Kit - EA100535 from Acris Antibodies Category ELISA Kit Prices $420.00 Sizes 1 kit Range 10

Rat neurotrophic tyrosine kinase, receptor, type 1 (NTRK1) ELISA Kit - EKC39484 from Biomatik Category ELISA Kit Prices $795.00, $3,021.00, $5,645.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.156 ng/ml Range 0.625 ng/ml-40 ng/ml

Rat Ntrk1 ELISA Kit - E091817 from Biobool Category ELISA Kit

High affinity nerve growth factor receptor, ELISA Kit - MBS2883916 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rat TrkA ELISA Kit - EK5381 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 96 t Range 156pg ml-10000pg ml

Rat Tropomyosin ELISA Kit - orb411137 from Biorbyt Category ELISA Kit

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