Ntrk1
| Gene Symbol | Ntrk1 |
|---|---|
| Entrez Gene | 59109 |
| Alt Symbol | Trk |
| Species | Rat |
| Gene Type | protein-coding |
| Description | neurotrophic tyrosine kinase, receptor, type 1 |
| Other Description | TrkA neurotrophin receptor|high affinity nerve growth factor receptor|p140-TrkA|slow nerve growth factor receptor|trk|trk-A|trkA proto-oncogene receptor|tropomyosin-related kinase A |
| Swissprots | P35739 |
| Accessions | EDM00771 EDM00772 P35739 AF174586 AAF77635 AF174587 AAF77636 M85214 AAA42286 XM_006232746 XP_006232808 NM_021589 NP_067600 |
| Function | Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras- PI3 kin |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Early endosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes. |
| Tissue Specificity | Isoform Trka-II is primarily expressed in neuronal cells; isoform Trka-I is found in non-neuronal tissues. |
| Top Pathways | Central carbon metabolism in cancer, Apoptosis, Inflammatory mediator regulation of TRP channels, Endocytosis, Neurotrophin signaling pathway |
Recombinant Rat TrkA Fc Chimera, CF - 1056-TK-050 from R&D Systems
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Rat TrkA protein - orb139811 from Biorbyt
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Recombinant Rat TrkA, FC Chimera - Ntrk1-589R from Creative Biomart
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Recombinant Rat Ntrk1, Fc tagged - Ntrk1-44R from Creative Biomart
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Recombinant Rat Ntrk1, His tagged - Ntrk1-45R from Creative Biomart
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Rat TrkA / NTRK1 Protein (His Tag) - 80404-R08H-50 from Sino Biological
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Rat TrkA / NTRK1 Protein (Fc Tag) - 80404-R02H-50 from Sino Biological
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Recombinant Rat High affinity nerve growth factor receptor(Ntrk1) - CSB-YP016133RA CSB-EP016133RA CSB-BP016133RA CSB-MP016133RA from Cusabio
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Recombinant Rat TrkA Fc Chimera Protein, CF - 1056-TK from R&D Systems
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Recombinant Rat TrkA / NTRK1 Protein (His tag) - PKSR030180 from Elabscience
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Recombinant Rat TrkA / NTRK1 Protein (Fc tag) - PKSR030181 from Elabscience
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Recombinant Rat NTRK1 Protein - NTRK1-4102R from Creative Biomart
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Rat TrkA / NTRK1 Protein (Fc Tag) - 80404-R02H from ABclonal
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High affinity nerve growth factor receptor, Recombinant Protein - MBS7043167 from MyBioSource
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High affinity nerve growth factor receptor (Ntrk1), Recombinant Protein - MBS953738 from MyBioSource
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