Ntrk1

Gene Symbol Ntrk1
Entrez Gene 59109
Alt Symbol Trk
Species Rat
Gene Type protein-coding
Description neurotrophic tyrosine kinase, receptor, type 1
Other Description TrkA neurotrophin receptor|high affinity nerve growth factor receptor|p140-TrkA|slow nerve growth factor receptor|trk|trk-A|trkA proto-oncogene receptor|tropomyosin-related kinase A
Swissprots P35739
Accessions EDM00771 EDM00772 P35739 AF174586 AAF77635 AF174587 AAF77636 M85214 AAA42286 XM_006232746 XP_006232808 NM_021589 NP_067600
Function Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras- PI3 kin
Subcellular Location Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Early endosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes.
Tissue Specificity Isoform Trka-II is primarily expressed in neuronal cells; isoform Trka-I is found in non-neuronal tissues.
Top Pathways Central carbon metabolism in cancer, Apoptosis, Inflammatory mediator regulation of TRP channels, Endocytosis, Neurotrophin signaling pathway

Anti-TrkA antibody - ab8871 from Abcam

Prices $392.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescent staining for TrkA obtained with TrkA antibody (ab8871) in rat DRG. Picture taken with X10 objective. Animals were intracardially perfused with 4% PFA. Tissue was post-fixed overnight in the same fixative, cryoprotected in 20% sucrose and frozen in OCT.  Protocol : IHC on 30um cryostat sections. Primary antibody ab8871 was used at 1/3000 and incubated overnight at room temperature. Secondary antibody, Alexa fluor 488 at 1/1000, incubated for 2 hours at room temperature.

Anti-TrkA antibody - ab72029 from Abcam

Host Sheep
Clonality Polyclonal

Anti-TrkA antibody - ab72066 from Abcam

Host Sheep
Clonality Polyclonal

Anti-TrkA antibody - ab72162 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-TrkA antibody - ab43416 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-TrkA antibody (ab43416) at 1/1000 dilutionLane 1 : (Left) ~20ug of a total protein extract from E coli with ~50ng to 100 ng of a tagged fusion protein of an irrelevant antigenLane 2 : (Right) ~20ug of a total protein extract from E coli with ~50ng to 500ng of the antigen (tag-antigen fusion protein)SecondaryRabbit anti-mouse IgG + IgM, (H+L) horseradish peroxidase conjugated at 1/5000 dilution

TrkA-extracellular-Antibody - AG1416 from Abgent, a WuXi AppTec company

Prices $375.00, $475.00, $575.00
Sizes 25 µl, 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain lysates: 1, 2. Anti-TrkA (extracellular) antibody (#AG1416), (1:200). 3, 4. Anti-TrkA (extracellular) antibody, preincubated with the control peptide antigen.

Anti-NTRK1 (aa 112-211) polyclonal antibody - DPABH-29051 from Creative Diagnostics

Host Mouse
Clonality Polyclonal

TrkA / NTRK1 Antibody, Rabbit PAb, Antigen Affinity Purified - 80404-T24-100 from Sino Biological

Prices $99.00, $99.00
Sizes 50 µg, 100 µg
Host Rabbit
Clonality Polyclonal

TrkA / NTRK1 Antibody, Rabbit PAb - 80404-RP01-200 from Sino Biological

Prices $99.00, $99.00
Sizes 100 µg, 200 µg
Host Rabbit
Clonality Polyclonal

TrkA Polyclonal Antibody - OST00115W from Thermo Fisher Scientific

Prices $309.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal

TrkA Polyclonal Antibody - OST00116G from Thermo Fisher Scientific

Prices $309.00
Sizes 500 µg
Host Sheep
Clonality Polyclonal

Milli-Mark™ Anti-TrkA-FITC Antibody - FCABS350F from EMD Millipore

Prices $269.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

Anti-TrkA Antibody - 06-574 from EMD Millipore

Prices $399.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal
<b>Immunohistochemistry Analysis: </b><br />Representative lot data. <br />Paraffin-embedded tissues of the hippocampal region (Fig. 1) and adrenal gland’s medulla (Fig. 2) were prepared using heat-induced epitope retrieval in citrate buffer, pH 6.0. Immunostaining was performed using a 1:200 dilution of Cat. No. 06-574, Anti-TrkA Reactivity was detected using the IHC-Select Detection Kit (Cat. No. DAB050). Immunoreactivity is expressed in human brain regions of higher cognitive processes and inside the adrenal medulla without nuclear involvement.

Anti-phospho-TrkA (Tyr794) Antibody - ABN1383 from EMD Millipore

Prices $279.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

TrkA (extracellular) Antibody - WGA1262 from WuXi Biosciences

Prices $275.00, $375.00, $475.00
Sizes 25 µl, 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain lysates: 1, 2. Anti-TrkA (extracellular) antibody (#WGA1262), (1:200). 3, 4. Anti-TrkA (extracellular) antibody, preincubated with the control peptide antigen.

TrkA antibody - TA328905 from Acris Antibodies

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain lysates: 1, 2. Anti-TrkA (extracellular) antibody , (1:200). 3, 4. Anti-TrkA (extracellular) antibody, preincubated with the control peptide antigen.

TrkA / NTRK1 Antibody, Rabbit PAb - 80404-RP01-400 from Sino Biological

Prices $99.00, $99.00
Sizes 100 µg, 200 µg
Host Rabbit
Clonality Polyclonal

TrkA / NTRK1 Antibody, Rabbit PAb, Antigen Affinity Purified - 80404-T24-200 from Sino Biological

Prices $99.00, $99.00, $99.00
Sizes 50 µg, 100 µg, 200 µg
Host Rabbit
Clonality Polyclonal
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