| Gene Symbol | Ntrk1 |
|---|---|
| Entrez Gene | 59109 |
| Alt Symbol | Trk |
| Species | Rat |
| Gene Type | protein-coding |
| Description | neurotrophic tyrosine kinase, receptor, type 1 |
| Other Description | TrkA neurotrophin receptor|high affinity nerve growth factor receptor|p140-TrkA|slow nerve growth factor receptor|trk|trk-A|trkA proto-oncogene receptor|tropomyosin-related kinase A |
| Swissprots | P35739 |
| Accessions | EDM00771 EDM00772 P35739 AF174586 AAF77635 AF174587 AAF77636 M85214 AAA42286 XM_006232746 XP_006232808 NM_021589 NP_067600 |
| Function | Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras- PI3 kin |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Early endosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes. |
| Tissue Specificity | Isoform Trka-II is primarily expressed in neuronal cells; isoform Trka-I is found in non-neuronal tissues. |
| Top Pathways | Central carbon metabolism in cancer, Apoptosis, Inflammatory mediator regulation of TRP channels, Endocytosis, Neurotrophin signaling pathway |