| Gene Symbol |
PSMA2
|
| Entrez Gene |
5683
|
| Alt Symbol |
HC3, MU, PMSA2, PSC2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proteasome (prosome, macropain) subunit, alpha type, 2
|
| Other Description |
macropain subunit C3|multicatalytic endopeptidase complex subunit C3|proteasome component C3|proteasome subunit HC3|proteasome subunit alpha type-2
|
| Swissprots |
P25787 Q9BU45 Q6ICS6
|
| Accessions |
CBF59431 CBU84675 EAL24005 EAW94151 EAW94152 EAW94153 P25787 AK222976 BAD96696 AK290654 BAF83343 AU120930 BC002900 AAH02900 BC047697 AAH47697 BX641097 CAE46046 CB990982 CR450317 CAG29313 D00760 BAA00657 HQ448587 ADQ33065 NM_002787 NP_002778
|
| Function |
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation.
|
| Subcellular Location |
Cytoplasm. Nucleus. Cytoplasm, P-body {ECO:0000250}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.
|
| Top Pathways |
Proteasome
|
![Western Blot: Proteasome 20S alpha 2 Overexpression Lysate (Adult Normal) [NBL1-14872] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Proteasome 20S alpha 2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7280_Proteasome%252020S%2520alpha%25202%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14872-img0002.jpg)