Gene Symbol | PSMA2 |
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Entrez Gene | 5683 |
Alt Symbol | HC3, MU, PMSA2, PSC2 |
Species | Human |
Gene Type | protein-coding |
Description | proteasome (prosome, macropain) subunit, alpha type, 2 |
Other Description | macropain subunit C3|multicatalytic endopeptidase complex subunit C3|proteasome component C3|proteasome subunit HC3|proteasome subunit alpha type-2 |
Swissprots | P25787 Q9BU45 Q6ICS6 |
Accessions | CBF59431 CBU84675 EAL24005 EAW94151 EAW94152 EAW94153 P25787 AK222976 BAD96696 AK290654 BAF83343 AU120930 BC002900 AAH02900 BC047697 AAH47697 BX641097 CAE46046 CB990982 CR450317 CAG29313 D00760 BAA00657 HQ448587 ADQ33065 NM_002787 NP_002778 |
Function | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation. |
Subcellular Location | Cytoplasm. Nucleus. Cytoplasm, P-body {ECO:0000250}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}. |
Top Pathways | Proteasome |
20S Proteasome α2 CRISPR/Cas9 KO Plasmid (h) - sc-401450 from Santa Cruz Biotechnology
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20S Proteasome α2 HDR Plasmid (h) - sc-401450-HDR from Santa Cruz Biotechnology
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20S Proteasome α2 Double Nickase Plasmid (h) - sc-401450-NIC from Santa Cruz Biotechnology
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20S Proteasome α2 Double Nickase Plasmid (h2) - sc-401450-NIC-2 from Santa Cruz Biotechnology
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20S Proteasome α2 CRISPR Activation Plasmid (h) - sc-401450-ACT from Santa Cruz Biotechnology
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20S Proteasome α2 CRISPR Activation Plasmid (h2) - sc-401450-ACT-2 from Santa Cruz Biotechnology
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20S Proteasome α2 Lentiviral Activation Particles (h) - sc-401450-LAC from Santa Cruz Biotechnology
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20S Proteasome α2 Lentiviral Activation Particles (h2) - sc-401450-LAC-2 from Santa Cruz Biotechnology
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20S Proteasome α2 siRNA (h) - sc-62876 from Santa Cruz Biotechnology
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20S Proteasome α2 shRNA Plasmid (h) - sc-62876-SH from Santa Cruz Biotechnology
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20S Proteasome α2 shRNA (h) Lentiviral Particles - sc-62876-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU011271 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17589 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17589 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06194 from Sigma-Aldrich
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PSMA2 siRNA (Human) - CRH3830 from Cohesion Biosciences
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shRNA set against Human PSMA2(NM_002787.4) - SHR146850 from Creative biogene
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Human PSMA2 siRNA - orb264332 from Biorbyt
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PSMA2 shRNA Plasmid (Human) - CHH3830 from Cohesion Biosciences
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PSMA2 miRNA 3'UTR clone - MiUTR1H-08373 from Creative biogene
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