| Gene Symbol | DPM2 |
|---|---|
| Entrez Gene | 8818 |
| Alt Symbol | CDG1U |
| Species | Human |
| Gene Type | protein-coding |
| Description | dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit |
| Other Description | DPM synthase complex subunit|DPM synthase subunit 2|dolichol phosphate-mannose biosynthesis regulatory protein|dolichol-phosphate mannose synthase subunit 2 |
| Swissprots | O94777 Q6FGH3 Q5XKK9 |
| Accessions | O94777 AB013361 BAA33974 AB451329 BAG70143 AB451473 BAG70287 AF061729 AAG43140 AI954002 AK312121 BAG35057 BC015233 AAH15233 BC015374 AAH15374 BC048256 BC107863 AAI07864 CR542134 CAG46931 NM_003863 NP_003854 NM_152690 |
| Function | Regulates the biosynthesis of dolichol phosphate- mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity. {ECO:0000269|PubMed:10944123}. |
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| Top Pathways | N-Glycan biosynthesis, Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |