Gene Symbol | DPM2 |
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Entrez Gene | 8818 |
Alt Symbol | CDG1U |
Species | Human |
Gene Type | protein-coding |
Description | dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit |
Other Description | DPM synthase complex subunit|DPM synthase subunit 2|dolichol phosphate-mannose biosynthesis regulatory protein|dolichol-phosphate mannose synthase subunit 2 |
Swissprots | O94777 Q6FGH3 Q5XKK9 |
Accessions | O94777 AB013361 BAA33974 AB451329 BAG70143 AB451473 BAG70287 AF061729 AAG43140 AI954002 AK312121 BAG35057 BC015233 AAH15233 BC015374 AAH15374 BC048256 BC107863 AAI07864 CR542134 CAG46931 NM_003863 NP_003854 NM_152690 |
Function | Regulates the biosynthesis of dolichol phosphate- mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity. {ECO:0000269|PubMed:10944123}. |
Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
Top Pathways | N-Glycan biosynthesis, Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
DPM2 CRISPR/Cas9 KO Plasmid (h) - sc-411216 from Santa Cruz Biotechnology
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DPM2 HDR Plasmid (h) - sc-411216-HDR from Santa Cruz Biotechnology
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DPM2 Double Nickase Plasmid (h) - sc-411216-NIC from Santa Cruz Biotechnology
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DPM2 Double Nickase Plasmid (h2) - sc-411216-NIC-2 from Santa Cruz Biotechnology
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DPM2 CRISPR Activation Plasmid (h) - sc-411216-ACT from Santa Cruz Biotechnology
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DPM2 CRISPR Activation Plasmid (h2) - sc-411216-ACT-2 from Santa Cruz Biotechnology
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DPM2 Lentiviral Activation Particles (h) - sc-411216-LAC from Santa Cruz Biotechnology
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DPM2 Lentiviral Activation Particles (h2) - sc-411216-LAC-2 from Santa Cruz Biotechnology
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DPM2 siRNA (h) - sc-41511 from Santa Cruz Biotechnology
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DPM2 shRNA Plasmid (h) - sc-41511-SH from Santa Cruz Biotechnology
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DPM2 shRNA (h) Lentiviral Particles - sc-41511-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU070531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7456 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7456 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05076 from Sigma-Aldrich
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DPM2 siRNA (Human) - CRH5816 from Cohesion Biosciences
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DPM2 - MBS8236879 from MyBioSource
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shRNA set against Human DPM2 (NM_003863.3) - SHH280617 from Creative biogene
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Human DPM2 siRNA - orb266318 from Biorbyt
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DPM2 shRNA Plasmid (Human) - CHH5816 from Cohesion Biosciences
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DPM2 miRNA 3'UTR clone - MiUTR3H-06070 from Creative biogene
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