| Gene Symbol |
DPM2
|
| Entrez Gene |
8818
|
| Alt Symbol |
CDG1U
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
|
| Other Description |
DPM synthase complex subunit|DPM synthase subunit 2|dolichol phosphate-mannose biosynthesis regulatory protein|dolichol-phosphate mannose synthase subunit 2
|
| Swissprots |
O94777 Q6FGH3 Q5XKK9
|
| Accessions |
O94777 AB013361 BAA33974 AB451329 BAG70143 AB451473 BAG70287 AF061729 AAG43140 AI954002 AK312121 BAG35057 BC015233 AAH15233 BC015374 AAH15374 BC048256 BC107863 AAI07864 CR542134 CAG46931 NM_003863 NP_003854 NM_152690
|
| Function |
Regulates the biosynthesis of dolichol phosphate- mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity. {ECO:0000269|PubMed:10944123}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein.
|
| Top Pathways |
N-Glycan biosynthesis, Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
|
![Western Blot: DPM2 Overexpression Lysate (Adult Normal) [NBL1-09993] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DPM2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7923_DPM2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09993-img0002.jpg)